Goh Tae Sik, Hong Changwan
Department of Anatomy, Pusan National University School of Medicine, Yangsan, Republic of Korea; Department of Orthopaedic Surgery, Medical Research Institute, Pusan National University School of Medicine, Busan, Republic of Korea.
Department of Anatomy, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Cytokine. 2017 Jan;89:179-184. doi: 10.1016/j.cyto.2015.12.009. Epub 2015 Dec 31.
The common gamma chain (γc) receptor family of cytokines including interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21 has the common feature of sharing γc signaling subunit of their receptors. The γc cytokines have unique biological effects that regulate differentiation, survival and activation of multiple lymphocyte lineages and control proliferation of malignant cell by influencing tumor environment. It has been also described that different types of lymphoid leukemia and lymphoma exhibit expression of divergent γc cytokines and their receptors, as they may promote malignant transformation of lymphoid cells or on the contrary lead to tumor regression by inducing cell-cycle arrest. Therefore, cytokine-based or cytokine-directed blockade in cancer immunotherapy has currently revolutionized the development of cancer treatment. In this review, we will discuss about the role of γc cytokines and their signaling pathways in hematological malignancies and also propose a novel alternative approach that regulates γc cytokine responsiveness by γc in hematological malignancies.
包括白细胞介素-2（IL-2）、IL-4、IL-7、IL-9、IL-15和IL-21在内的细胞因子的共同γ链（γc）受体家族具有其受体共享γc信号亚基的共同特征。γc细胞因子具有独特的生物学效应，可调节多种淋巴细胞谱系的分化、存活和激活，并通过影响肿瘤环境来控制恶性细胞的增殖。也有描述称，不同类型的淋巴白血病和淋巴瘤表现出不同γc细胞因子及其受体的表达，因为它们可能促进淋巴细胞的恶性转化，或者相反，通过诱导细胞周期停滞导致肿瘤消退。因此，基于细胞因子或细胞因子导向的癌症免疫治疗阻断目前彻底改变了癌症治疗的发展。在这篇综述中，我们将讨论γc细胞因子及其信号通路在血液系统恶性肿瘤中的作用，并提出一种新的替代方法，即通过γc调节血液系统恶性肿瘤中γc细胞因子的反应性。
