Bégué P, Baron S, Borderon J C, Quinet B
Service Médecine Consultations, Hôpital Trousseau, Paris.
Pathol Biol (Paris). 1989 May;37(5):481-4.
Ceftizoxime was evaluated in the treatment of 49 children and 15 neonates. The average dosage was 150 mg/kg/d for newborns and 115 mg/kg/d for children, administered IV, 3 or 4 times daily. Clinical and bacteriological cure was achieved in 93% children and 92% neonates. The clinical and biological tolerance was very good. Pharmacokinetic parameters were studied in 17 patients, including 2 neonates. In children the mean serum peak was 40 mug/ml and the mean half life was 2.2 +/- 0.6 H, after a dose of 30 mg/kg. In both neonates the half life was 3.1 H and 3.6 H. In urine, mean concentration of 4 g/l has been obtained in the first 2 hours after IV.
对头孢唑肟治疗49名儿童和15名新生儿进行了评估。新生儿平均剂量为150mg/kg/天，儿童为115mg/kg/天，静脉注射，每日3或4次。93%的儿童和92%的新生儿实现了临床和细菌学治愈。临床和生物学耐受性非常好。对17名患者（包括2名新生儿）进行了药代动力学参数研究。儿童在给予30mg/kg剂量后，平均血清峰值为40μg/ml，平均半衰期为2.2±0.6小时。两名新生儿的半衰期分别为3.1小时和3.6小时。静脉注射后最初2小时内，尿液中的平均浓度达到4g/l。
