Greenwood-Van Meerveld B, Moloney R D, Johnson A C, Vicario M
Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA.
V.A. Medical Center, Oklahoma City, OK, USA.
J Neuroendocrinol. 2016 Aug;28(8). doi: 10.1111/jne.12361.
Visceral pain is a term describing pain originating from the internal organs of the body and is a common feature of many disorders, including irritable bowel syndrome (IBS). Stress is implicated in the development and exacerbation of many visceral pain disorders. Recent evidence suggests that stress and the gut microbiota can interact through complementary or opposing factors to influence visceral nociceptive behaviours. The Young Investigator Forum at the International Society of Psychoneuroendocrinology (ISPNE) annual meeting reported experimental evidence suggesting the gut microbiota can affect the stress response to affect visceral pain. Building upon human imaging data showing abnormalities in the central processing of visceral stimuli in patients with IBS and knowledge that the amygdala plays a pivotal role in facilitating the stress axis, the latest experimental evidence supporting amygdala-mediated mechanisms in stress-induced visceral pain was reviewed. The final part of the session at ISPNE reviewed experimental evidence suggesting that visceral pain in IBS may be a result, at least in part, of afferent nerve sensitisation following increases in epithelial permeability and mucosal immune activation.
内脏痛是一个描述源自身体内部器官疼痛的术语，是包括肠易激综合征（IBS）在内的许多疾病的常见特征。压力与许多内脏痛疾病的发生和加重有关。最近的证据表明，压力和肠道微生物群可以通过互补或相反的因素相互作用，以影响内脏伤害感受行为。国际精神神经内分泌学会（ISPNE）年会的青年研究者论坛报告了实验证据，表明肠道微生物群可以影响应激反应以影响内脏痛。基于显示IBS患者内脏刺激的中枢处理存在异常的人体成像数据，以及杏仁核在促进应激轴方面起关键作用的知识，对支持杏仁核介导的应激诱导内脏痛机制的最新实验证据进行了综述。ISPNE会议的最后一部分回顾了实验证据，表明IBS中的内脏痛可能至少部分是上皮通透性增加和黏膜免疫激活后传入神经致敏的结果。
