[RESEARCH PROGRESS OF microRNA IN INTERVERTEBRAL DISC DEGENERATION].

OBJECTIVE

To comprehensively analyze the relationship between microRNAs and intervertebral disc degeneration at home and abroad.

METHODS

The literature about the relationship between microRNAs and intervertebral disc degeneration was reviewed and analyzed.

RESULTS

MicroRNA can lead to intervertebral disc degeneration by regulating the gene expression, thus influencing the cell's apoptosis and proliferation, increasing of the production of inflammatory mediator and protease, which play important roles in intervertebral disc degeneration.

CONCLUSION

MicroRNA is a research focus in the field of intervertebral disc degeneration. Further research of the relationship between microRNAs and intervertebral disc degeneration will help to identify the pathogenesis of intervertebral disc degeneration and furnish the new ideal for the diagnosis and treatment of intervertebral disc degeneration.