硫醇化-2-甲基丙烯酰氧乙基磷酰胆碱保护的银纳米颗粒作为新型光诱导细胞杀伤剂。
Thiolated-2-methacryloyloxyethyl phosphorylcholine protected silver nanoparticles as novel photo-induced cell-killing agents.
作者信息
Sangsuwan Arunee, Kawasaki Hideya, Iwasaki Yasuhiko
机构信息
Graduate School of Science and Engineering, Kansai University, 3-3-35 Yamate-Cho, Suita-Shi, Osaka 564-0836, Japan.
Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-Cho, Suita-Shi, Osaka 564-0836, Japan; ORDIST, Kansai University, 3-3-35 Yamate-Cho, Suita-Shi, Osaka 564-0836, Japan.
出版信息
Colloids Surf B Biointerfaces. 2016 Apr 1;140:128-134. doi: 10.1016/j.colsurfb.2015.12.037. Epub 2015 Dec 24.
Silver nanoparticles (AgNPs) have several medical applications as antimicrobial agents such as in drug delivery and cancer therapy. However, AgNPs are of limited use because of their toxicity, which may damage the surrounding healthy tissue. In this study, thiolated-2-methacryloyloxyethyl phosphorylcholine (MPC-SH) protected silver nanoparticles (MPC-AgNPs) are prepared as cell-killing agents under UV irradiation. MPC-AgNPs are characterized by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and UV-visible spectrophotometry. The surface plasmon resonance (SPR) band of MPC-AgNPs is observed at 404 nm, and the average diameter of the particles is determined at 13.4 ± 2.2 nm through transmission electron microscopy (TEM) and at 18.4 nm (PDI=0.18) through dynamic light scattering (DLS). Cell viability in contact with MPC-AgNPs is relatively high, and MPC-AgNPs also exhibit a cell-killing effect under UV irradiation.
银纳米颗粒（AgNPs）作为抗菌剂在药物递送和癌症治疗等多种医学应用中有所使用。然而，由于其毒性可能会损害周围健康组织，AgNPs的用途有限。在本研究中，制备了巯基化2-甲基丙烯酰氧基乙基磷酰胆碱（MPC-SH）保护的银纳米颗粒（MPC-AgNPs）作为紫外线照射下的细胞杀伤剂。MPC-AgNPs通过X射线衍射（XRD）、X射线光电子能谱（XPS）和紫外可见分光光度法进行表征。MPC-AgNPs的表面等离子体共振（SPR）带在404nm处观察到，通过透射电子显微镜（TEM）测定颗粒的平均直径为13.4±2.2nm，通过动态光散射（DLS）测定为18.4nm（PDI = 0.18）。与MPC-AgNPs接触时细胞活力相对较高，并且MPC-AgNPs在紫外线照射下也表现出细胞杀伤作用。
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