转移性甲状腺髓样癌患者的（18）F-FDG-PET/CT和（111）In-奥曲肽SPECT多模态成像

Multimodal imaging with (18)F-FDG-PET/CT and (111)In-Octreotide SPECT in patients with metastatic medullary thyroid carcinoma.

作者信息

De Luca Serena, Fonti Rosa, Camera Luigi, Salvatore Barbara, Faggiano Antongiulio, Ciarmiello Andrea, Segreto Sabrina, Colao Annamaria, Salvatore Marco, Del Vecchio Silvana

机构信息

Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Edificio 10, 80131, Naples, Italy.

Institute of Biostructures and Bioimages, National Research Council, Naples, Italy.

出版信息

Ann Nucl Med. 2016 Apr;30(3):234-41. doi: 10.1007/s12149-015-1056-5. Epub 2016 Jan 11.

DOI:10.1007/s12149-015-1056-5

PMID:26753628

Abstract

OBJECTIVE

The aim of our study was to determine the role of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG-PET/CT) and indium-111 Octreotide single photon emission tomography ((111)In-Octreotide SPECT) in the evaluation of metastatic medullary thyroid carcinoma (MMTC).

METHODS

Twenty-five MMTC patients were retrospectively evaluated. All patients had undergone whole-body (18)F-FDG-PET/CT including 20 who had also undergone (111)In-Octreotide SPECT within a maximum interval of 6 weeks. Diagnostic contrast-enhanced computed tomography (CT) alone or as part of (18)F-FDG-PET/CT examination was performed in all patients.

RESULTS

Contrast-enhanced CT detected a total of 131 lesions including 79 enlarged lymph nodes and 14 bone lesions. (18)F-FDG-PET/CT visualized a total of 92 true positive lesions (SUVmax range 1.1-10.0, mean 4.0 ± 1.7) including 66 lymph nodes, 7 of which were not enlarged on CT, and 8 bone metastases. In the 20 patients studied with both techniques, a total of 64 and 46 true positive lesions were detected by (18)F-FDG-PET/CT and (111)In-Octreotide SPECT, respectively. In particular, (18)F-FDG uptake was found in 43 lymph nodes and in 7 bone metastases whereas (111)In-Octreotide uptake was detected in 27 lymph nodes and in 10 bone metastases.

CONCLUSIONS

In MMTC patients, (18)F-FDG-PET/CT provides a useful contribution mainly in evaluating lymph node involvement whereas (111)In-Octreotide SPECT can contribute to the detection and somatostatin receptor characterization especially of bone lesions.

摘要

目的

本研究旨在确定氟-18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（(18)F-FDG-PET/CT）和铟-111奥曲肽单光子发射断层扫描（(111)In-奥曲肽SPECT）在转移性甲状腺髓样癌（MMTC）评估中的作用。

方法

对25例MMTC患者进行回顾性评估。所有患者均接受了全身(18)F-FDG-PET/CT检查，其中20例在最长6周的间隔内还接受了(111)In-奥曲肽SPECT检查。所有患者均进行了单纯的诊断性增强计算机断层扫描（CT）或作为(18)F-FDG-PET/CT检查的一部分。

结果

增强CT共检测到131个病灶，包括79个肿大淋巴结和14个骨病灶。(18)F-FDG-PET/CT共显示92个真阳性病灶（SUVmax范围为1.1-10.0，平均4.0±1.7），包括66个淋巴结，其中7个在CT上未肿大，以及8个骨转移灶。在同时采用这两种技术研究的20例患者中，(18)F-FDG-PET/CT和(111)In-奥曲肽SPECT分别检测到64个和46个真阳性病灶。特别是，在43个淋巴结和7个骨转移灶中发现了(18)F-FDG摄取，而在27个淋巴结和10个骨转移灶中检测到了(111)In-奥曲肽摄取。