基质金属蛋白酶2、3和9基因的遗传多态性与中国汉族人群骨肉瘤易感性

Genetic polymorphisms in MMP 2, 3 and 9 genes and the susceptibility of osteosarcoma in a Chinese Han population.

作者信息

Cui Yan, Zhu Jia-Jun, Ma Cheng-Bin, Cui Kai, Wang Feng, Ni Sheng-Hui, Zhang Zhi-Yu

机构信息

a Department of Orthopaedics , The Fourth Affiliated Hospital of China Medical University , Shenyang , Liaoning Province , China.

出版信息

Biomarkers. 2016;21(2):160-3. doi: 10.3109/1354750X.2015.1118550. Epub 2016 Jan 12.

DOI:10.3109/1354750X.2015.1118550

PMID:26754027

Abstract

BACKGROUND

There are no data about the role of MMPs polymorphism in development of osteosarcoma.

PATIENTS AND METHODS

Two-hundred fifty-one patients with osteosarcoma and 251 healthy controls were included to investigate the association between the MMP2, 3, 9 polymorphisms and the risk of osteosarcoma.

RESULTS

Compared with the MMP2 SNP rs243865 homozygote CC, The heterozygous CT genotype was associated with significantly increased risk for osteosarcoma (OR = 1.86, 95% CI = 1.18-4.22, p = 0.014); the TT genotype was associated with increased risk for osteosarcoma (OR = 1.92, 95% CI = 1.21-3.52, p = 0.028). However, the genotype and allele frequencies of MMP3 rs3025058 and MMP9 rs3918242 polymorphisms were not significantly different.

CONCLUSION

MMP2 rs243865 genotype was associated with increased risk for development of osteosarcoma in Chinese Han population.

摘要

背景

关于基质金属蛋白酶（MMPs）多态性在骨肉瘤发生中的作用尚无相关数据。

患者与方法

纳入251例骨肉瘤患者和251例健康对照，以研究MMP2、3、9基因多态性与骨肉瘤风险之间的关联。

结果

与MMP2单核苷酸多态性（SNP）rs243865纯合子CC相比，杂合子CT基因型与骨肉瘤风险显著增加相关（比值比[OR]=1.86，95%置信区间[CI]=1.18 - 4.22，p = 0.014）；TT基因型与骨肉瘤风险增加相关（OR = 1.92，95% CI = 1.21 - 3.52，p = 0.028）。然而，MMP3 rs3025058和MMP9 rs3918242基因多态性的基因型和等位基因频率无显著差异。