血浆中F-肌动蛋白水平及F:G-肌动蛋白比率作为脓毒性休克患者潜在的新型生物标志物。
Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock.
作者信息
Belsky Justin B, Morris Daniel C, Bouchebl Ralph, Filbin Michael R, Bobbitt Kevin R, Jaehne Anja K, Rivers Emanuel P
机构信息
a Department of Emergency Medicine , Massachusetts General Hospital , Boston , MA , USA .
b Department of Emergency Medicine , Henry Ford Hospital , Detroit , MI , USA .
出版信息
Biomarkers. 2016;21(2):180-5. doi: 10.3109/1354750X.2015.1126646. Epub 2016 Jan 12.
OBJECTIVE
To compare plasma levels of F-actin, G-actin and thymosin beta 4 (TB4) in humans with septic shock, noninfectious systemic inflammatory response syndrome (SIRS) and healthy controls.
RESULTS
F-actin was significantly elevated in septic shock as compared with noninfectious SIRS and healthy controls. G-actin levels were greatest in the noninfectious SIRS group but significantly elevated in septic shock as compared with healthy controls. TB4 was not detectable in the septic shock or noninfectious SIRS group above the assay's lowest detection range (78 ng/ml).
CONCLUSIONS
F-actin is significantly elevated in patients with septic shock as compared with noninfectious SIRS. F-actin and the F:G-actin ratio are potential biomarkers for the diagnosis of septic shock.
目的
比较脓毒性休克患者、非感染性全身炎症反应综合征（SIRS）患者和健康对照者血浆中F-肌动蛋白、G-肌动蛋白和胸腺素β4（TB4）的水平。
结果
与非感染性SIRS和健康对照者相比，脓毒性休克患者的F-肌动蛋白显著升高。非感染性SIRS组的G-肌动蛋白水平最高，但与健康对照者相比，脓毒性休克患者的G-肌动蛋白水平显著升高。在脓毒性休克或非感染性SIRS组中，TB4在检测方法的最低检测范围（78 ng/ml）以上未被检测到。
结论
与非感染性SIRS相比，脓毒性休克患者的F-肌动蛋白显著升高。F-肌动蛋白和F:G-肌动蛋白比值是诊断脓毒性休克的潜在生物标志物。
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