Gani Cihan, Schroeder Christopher, Heinrich Vanessa, Spillner Patrick, Lamprecht Ulf, Berger Bernhard, Zips Daniel
Int J Hyperthermia. 2016;32(2):187-92. doi: 10.3109/02656736.2015.1117661. Epub 2016 Jan 11.
The aim of this study was to evaluate the impact of deep regional hyperthermia on long-term local control and survival in locally advanced non-metastatic rectal cancer.
In total 103 patients with locally advanced non-metastatic rectal cancer were treated preoperatively with either neoadjuvant radiochemotherapy alone (n = 43) or the same treatment with additional deep regional hyperthermia (n = 60). The two groups were compared with respect to local control, overall survival (OS), disease-free survival (DFS), and distant metastases-free survival (DMFS).
Patients receiving additional hyperthermia had excellent long-term local control with a 5-year Kaplan-Meier estimate of 98% compared with 87% in the radiochemotherapy only group (p = 0.09). Five-year rates for OS (88% versus 76%, p = 0.08), DFS (77% versus 73%, p = n.s.) and DMFS (75% versus 77%, p = n.s.) were not statistically different between the two groups.
Radiochemotherapy combined with hyperthermia results in excellent long-term local control.
本研究旨在评估深部区域热疗对局部晚期非转移性直肠癌长期局部控制率和生存率的影响。
总共103例局部晚期非转移性直肠癌患者在术前接受了单独的新辅助放化疗（n = 43）或相同治疗加深部区域热疗（n = 60）。比较两组的局部控制率、总生存期（OS）、无病生存期（DFS）和无远处转移生存期（DMFS）。
接受额外热疗的患者长期局部控制效果良好，5年Kaplan-Meier估计值为98%，而仅接受放化疗的组为87%（p = 0.09）。两组的5年总生存期（88%对76%，p = 0.08）、无病生存期（77%对73%，p = 无统计学差异）和无远处转移生存期（75%对77%，p = 无统计学差异）无统计学差异。
放化疗联合热疗可实现良好的长期局部控制。
