Tseleni-Balafouta S, Balafoutas A C, Paraskevakou H
Pathologischen Institut, Universität Athen.
Zentralbl Gynakol. 1989;111(11):744-8.
We studied 75 cervical biopsies (39 cases with CIN I-III and 36 with invasive squamous carcinoma differentiated to various degrees) immunohistochemically to determine the beta 2-m content of the epithelial cells. In cells having CIN we found a clear decrease in beta 2-m with a statistically significant correlation to the degrees of severity of the lesion. All of the invasive carcinomas showed a complete absence of beta 2-m. This finding should be evaluated within the framework of an immunological dedifferentiation, and it supports the views regarding the neoplastic nature of cervical dysplasia. The demonstration of beta 2-m in atypical epithelial cells of the cervix is a possible indication for the intraepithelial localisation of the lesion.
我们对75例宫颈活检组织（39例CIN I - III级病例和36例不同程度分化的浸润性鳞状细胞癌）进行免疫组化研究，以确定上皮细胞中的β2 - m含量。在患有CIN的细胞中，我们发现β2 - m明显减少，且与病变严重程度具有统计学显著相关性。所有浸润性癌均显示完全不存在β2 - m。这一发现应在免疫去分化的框架内进行评估，并且支持了关于宫颈发育异常的肿瘤性质的观点。宫颈非典型上皮细胞中β2 - m的显示可能提示病变的上皮内定位。
