类风湿性关节炎与痴呆风险：一项系统综述和荟萃分析。
Rheumatoid arthritis and the risk of dementia: A systematic review and meta-analysis.
作者信息
Ungprasert Patompong, Wijarnpreecha Karn, Thongprayoon Charat
机构信息
Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; Department of Medicine, Division of Rheumatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, .
出版信息
Neurol India. 2016 Jan-Feb;64(1):56-61. doi: 10.4103/0028-3886.173623.
BACKGROUND
The association between chronic inflammation and dementia has been identified in several epidemiologic studies. However, the data on rheumatoid arthritis (RA), one of the most common chronic inflammatory disorders, remains unclear.
MATERIALS AND METHODS
We conducted a systematic review and meta-analysis of cohort, case-control, and cross-sectional studies that compared the risk of dementia in patients with RA versus non-RA controls. Data from each study were combined using random-effect, generic inverse variance method of DerSimonian and Laird to calculate the pooled risk ratio (RR) and 95% confidence interval (CI).
RESULTS
Three cohort studies and two cross-sectional studies were identified and included in the meta-analysis. We found a significantly increased risk of dementia among patients with RA, with the pooled risk ratio of 1.61 (95% CI, 1.10-2.37). The statistical heterogeneity was high, with an I2 of 91%.
CONCLUSIONS
Our study demonstrated a statistically significant increase in the risk of dementia among patients with RA.
背景
多项流行病学研究已证实慢性炎症与痴呆之间存在关联。然而，关于类风湿关节炎（RA）这一最常见的慢性炎症性疾病之一的数据仍不明确。
材料与方法
我们对队列研究、病例对照研究和横断面研究进行了系统评价和荟萃分析，比较了类风湿关节炎患者与非类风湿关节炎对照者患痴呆的风险。使用DerSimonian和Laird的随机效应、通用逆方差方法合并每项研究的数据，以计算合并风险比（RR）和95%置信区间（CI）。
结果
确定了三项队列研究和两项横断面研究并纳入荟萃分析。我们发现类风湿关节炎患者患痴呆的风险显著增加，合并风险比为1.61（95%CI，1.10 - 2.37）。统计异质性较高，I²为91%。
结论
我们的研究表明，类风湿关节炎患者患痴呆的风险在统计学上显著增加。
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