阿尔茨海默病中的氧化应激挑战：知识现状与未来需求

Oxidative challenge in Alzheimer's disease: state of knowledge and future needs.

作者信息

Cervellati Carlo, Wood Paul L, Romani Arianna, Valacchi Giuseppe, Squerzanti Monica, Sanz Juana Maria, Ortolani Beatrice, Zuliani Giovanni

机构信息

Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics University of Ferrara, Ferrara, Italy.

Metabolomics Unit, Math and Science Building, Lincoln Memorial University, Harrogate, Tennessee, USA.

出版信息

J Investig Med. 2016 Jan;64(1):21-32. doi: 10.1136/jim-2015-000017.

DOI:10.1136/jim-2015-000017

PMID:26755810

Abstract

A large body of experimental and postmortem findings indicate that Alzheimer's disease (AD) is associated with increased oxidative stress (OxS) levels in the brain. Despite the current limitations of OxS assessment in living subjects, recent data suggest that oxidative challenge might increase early both in the central nervous system and peripheral fluids. The aim of this review was to provide an overview of the existing literature linking systemic OxS to brain OxS in AD. We firmly believe that continued research aimed at overcoming the methodological and design issues affecting the body of studies in this field is mandatory for successful development of an effective antioxidant-based treatment of AD.

摘要

大量实验和尸检结果表明，阿尔茨海默病（AD）与大脑中氧化应激（OxS）水平升高有关。尽管目前在活体受试者中评估氧化应激存在局限性，但近期数据表明，氧化应激挑战可能在中枢神经系统和外周液中均早期增加。本综述的目的是概述将全身氧化应激与AD中的脑氧化应激联系起来的现有文献。我们坚信，持续开展旨在克服影响该领域研究主体的方法学和设计问题的研究，对于成功开发基于抗氧化剂的AD有效治疗方法至关重要。