Wang Ying, Wang Haibao, Yu Yongqiang, Xu Liyan, Chen Yuping, Wu De
Department of Radiology, First Affiliated Hospital of Anhui Medical University, Hefei 230000, China.
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Zhonghua Er Ke Za Zhi. 2015 Sep;53(9):696-700.
To measure gray matter volume of whole brain with voxel-based morphometry (VBM) method and to study brain structures associated with gross motor function.
Forty children with cerebral palsy were recruited in the authors' hospital from Oct. 2012 to Dec. 2013 (26 male, 14 female cases, average age (3.6 ± 2.0) years ). Gross motor function classification system (GMFCS) for children was used to obtain their motor function. The whole-brain three dimensional magnetic resonance imaging (MRI) was performed on a 3.0 T MRI scanner. The data were segmented by VBM 5, and the whole brain volumes of gray matter, white matter and cerebospinal fluid were produced. Correlation analysis was used to analyze the correlation of GMFCS with whole brain volumes using SPM 5 in Matalab 7.1.
The volume in left meditemporal gyrus (Z=3.57) and inferior temporal gyrus (Z=3.40), right thalamus and pallidum (Z=3.36), left thalamus and pallidum (Z=2.76), left supramarginal gyrus (Z=3.14), left precuneus gyrus (Z=3.00), right dorsolateral superior frontal gyrus (Z=3.08), right superior and medial occipital gyrus (Z=2.84) significantly increased as aggravation of gross motor dysfunction. The volume of the left medial orbitofrontal lobe and anterior cingulate (Z=3.28,3.02), left medial superior frontal gyrus (Z=3.19), left caudate (Z=3.04, 2.94, 2.92), left cerebellum (Z=2.94), right cerebellum (Z=2.97), left parahippocampal (Z=3.94), right parahippocampal (Z=3.43, 3.00), left insula (Z=3.50), right insula (Z=3.41, 3.80), left lingual (Z=3.37), right lingual (Z=3.30), left post cingulum (Z=2.73), left midioccipital gyrus (Z=2.92) and right miditemporal gyrus (Z=3.05) significantly reduced as the aggravation of gross motor dysfunction (P all<0.005).
GMFCS in children with cerebral palsy is related to abnormalities of brain gray matter structure for motor, emotion, memory and default model network when examined with VBM method.
采用基于体素的形态测量法（VBM）测量全脑灰质体积，并研究与粗大运动功能相关的脑结构。
2012年10月至2013年12月在作者所在医院招募了40例脑瘫患儿（男26例，女14例，平均年龄（3.6±2.0）岁）。采用儿童粗大运动功能分类系统（GMFCS）获取其运动功能。在3.0T磁共振成像（MRI）扫描仪上进行全脑三维MRI检查。数据用VBM 5进行分割，生成全脑灰质、白质和脑脊液体积。使用Matalab 7.1中的SPM 5进行相关分析，分析GMFCS与全脑体积的相关性。
随着粗大运动功能障碍加重，左侧颞中回（Z=3.57）、颞下回（Z=3.40）、右侧丘脑和苍白球（Z=3.36）、左侧丘脑和苍白球（Z=2.76）、左侧缘上回（Z=3.14）、左侧楔前回（Z=3.00）、右侧背外侧额上回（Z=3.08）、右侧枕上回和枕中回（Z=2.84）体积显著增加。随着粗大运动功能障碍加重，左侧眶额内侧叶和前扣带回（Z=3.28，3.02）、左侧额上内侧回（Z=3.19）、左侧尾状核（Z=3.04，2.94，2.92）、左侧小脑（Z=2.94）、右侧小脑（Z=2.97）、左侧海马旁回（Z=3.94）、右侧海马旁回（Z=3.43，3.00）、左侧岛叶（Z=3.50）、右侧岛叶（Z=3.41，3.80）、左侧舌回（Z=3.37）、右侧舌回（Z=3.30）、左侧后扣带（Z=2.73）、左侧枕中回（Z=2.92）和右侧颞中回（Z=3.05）体积显著减小（P均<0.005）。
采用VBM方法检查时，脑瘫患儿的GMFCS与运动、情感、记忆和默认模式网络的脑灰质结构异常有关。
