男性和女性的生育状况与全因死亡率：队列研究的剂量反应荟萃分析
Parity and All-cause Mortality in Women and Men: A Dose-Response Meta-Analysis of Cohort Studies.
作者信息
Zeng Yun, Ni Ze-min, Liu Shu-yun, Gu Xue, Huang Qin, Liu Jun-an, Wang Qi
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Women and Children Medical Center of Jiang-an District, Wuhan, Hubei Province, China.
出版信息
Sci Rep. 2016 Jan 13;6:19351. doi: 10.1038/srep19351.
To quantitatively assess the association between parity and all-cause mortality, we conducted a meta-analysis of cohort studies. Relevant reports were identified from PubMed and Embase databases. Cohort studies with relative risks (RRs) and 95% confidence intervals (CIs) of all-cause mortality in three or more categories of parity were eligible. Eighteen articles with 2,813,418 participants were included. Results showed that participants with no live birth had higher risk of all-cause mortality (RR= 1.19, 95% CI = 1.03-1.38; I(2) = 96.7%, P < 0.001) compared with participants with one or more live births. Nonlinear dose-response association was found between parity and all-cause mortality (P for non-linearity < 0.0001). Our findings suggest that moderate-level parity is inversely associated with all-cause mortality.
为了定量评估生育次数与全因死亡率之间的关联，我们对队列研究进行了荟萃分析。从PubMed和Embase数据库中检索相关报告。纳入了具有三个或更多生育次数类别全因死亡率相对风险（RR）和95%置信区间（CI）的队列研究。共纳入18篇文章，涉及2813418名参与者。结果显示，与有一次或多次活产的参与者相比，无活产的参与者全因死亡风险更高（RR = 1.19，95% CI = 1.03 - 1.38；I(2) = 96.7%，P < 0.001）。生育次数与全因死亡率之间存在非线性剂量反应关联（非线性P < 0.0001）。我们的研究结果表明，中等生育次数与全因死亡率呈负相关。
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