成纤维细胞生长因子受体 4：慢性肾脏病与 FGF23 诱导的左心室肥厚之间缺失的一环？
Fibroblast growth factor receptor 4: the missing link between chronic kidney disease and FGF23-induced left ventricular hypertrophy?
机构信息
Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Institut National de la Santé et de la Recherche Médicale (INSERM) U-1018, Team 5, Hôpital Paul Brousse, Paris-Sud University and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University), Villejuif, France.
出版信息
Kidney Int. 2016 Jan;89(1):7-9. doi: 10.1016/j.kint.2015.11.012.
Serum phosphorus and the regulatory hormone fibroblast growth factor 23 have been strongly linked to cardiovascular morbidity and mortality in patients with chronic kidney disease. A recent study identified fibroblast growth factor receptor 4 as the primary receptor mediating the effect of fibroblast growth factor 23 on left ventricular hypertrophy, providing new mechanistic insights and a potential therapeutic target to reduce cardiovascular morbidity in chronic kidney disease.
血清磷和调节激素成纤维细胞生长因子 23 与慢性肾脏病患者的心血管发病率和死亡率密切相关。最近的一项研究确定成纤维细胞生长因子受体 4 为介导成纤维细胞生长因子 23 对左心室肥厚影响的主要受体，为降低慢性肾脏病的心血管发病率提供了新的机制见解和潜在的治疗靶点。
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