人输卵管蛋白质组显示间充质干细胞相关蛋白的高覆盖率。
Human fallopian tube proteome shows high coverage of mesenchymal stem cells associated proteins.
作者信息
Wang Chenyuan, Liu Yang, Chang Cheng, Wu Songfeng, Gao Jie, Zhang Yang, Chen Yingjie, Zhong Fan, Deng Gaopi
机构信息
Gynecology Department, The First Clinical Medical School, Guangzhou University of Chinese Medicine, 12 Jichang Blvd, Guangzhou 510405, China.
Department of Systems Biology for Medicine, Shanghai Medical College, and Institutes of Biomedical Sciences, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China.
出版信息
Biosci Rep. 2016 Jan 12;36(1):e00297. doi: 10.1042/BSR20150220.
The object of this research was to report a draft proteome of human fallopian tube (hFT) comprises 5416 identified proteins, which could be considered as a physiological reference to complement Human Proteome Draft. The proteomic raw data and metadata were stored in an integrated proteome resources centre iProX (IPX00034300). This hFT proteome contains many hFT markers newly identified by mass spectrum. This hFT proteome comprises 660 high-, 3605 medium- and 1181 low-abundant proteins. Ribosome, cytoskeleton, vesicle and protein folding associated proteins showed obvious tendency to be higher abundance in hFT. The extraordinary high coverage of mesenchymal stem cells (MSCs)-associated proteins were identified in this hFT proteome, which highly supported that hFT should contain a plenty of MSCs.
本研究的目的是报告一份包含5416种已鉴定蛋白质的人输卵管蛋白质组草图，该草图可作为补充人类蛋白质组草图的生理学参考。蛋白质组学原始数据和元数据存储在综合蛋白质组资源中心iProX（IPX00034300）中。这个人输卵管蛋白质组包含许多通过质谱新鉴定的人输卵管标记物。这个人输卵管蛋白质组包括660种高丰度、3605种中等丰度和1181种低丰度蛋白质。核糖体、细胞骨架、囊泡和与蛋白质折叠相关的蛋白质在人输卵管中呈现出明显的高丰度趋势。在这个人输卵管蛋白质组中鉴定出了与间充质干细胞（MSC）相关蛋白质的极高覆盖率，这有力地支持了人输卵管应含有大量间充质干细胞的观点。
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