2010 - 2011年伊朗戈勒斯坦省高危婴儿感音神经性听力损失的危险因素
Risk Factors for Sensorineural Hearing Loss Among High-Risk Infants in Golestan Province, Iran in 2010 - 2011.
作者信息
Alaee Ehsan, Sirati Mohsen, Taziki Mohammad Hossein, Fouladinejad Mahnaz
机构信息
Neonatal and Children's Health Research Center, Golestan University of Medical Sciences, Gorgan, IR Iran.
School of Medicine, Golestan University of Medical Sciences, Gorgan, IR Iran.
出版信息
Iran Red Crescent Med J. 2015 Dec 20;17(12):e20419. doi: 10.5812/ircmj.20419. eCollection 2015 Dec.
BACKGROUND
Hearing impairment, as one of the most common birth defects, is a hidden disability with negative impacts on speech and cognitive development.
OBJECTIVES
The aim of this study was to assess the prevalence of sensorineural hearing loss (SNHL) and determine the associated risk factors among infants admitted to neonatal intensive care units (NICUs) and neonatal wards of teaching hospitals, affiliated to Golestan University of Medical Sciences, Gorgan, Iran.
PATIENTS AND METHODS
In this cross-sectional study, 791 infants were recruited via non-random sampling. Demographic and clinical characteristics of the subjects were gathered, and the Automated Auditory Brainstem Response (AABR) test was performed upon admission. Afterwards, the subjects were followed-up and re-assessed, using the AABR test. For infants with abnormal AABR results, the Auditory Brainstem Response (ABR) test was performed on the day of discharge.
RESULTS
The mean age of the infants was 3.75 ± 4.86 days upon admission, and 56.4% of the subjects were female. The mean length of hospital stay was 9.63 ± 1.1 days; the subjects were hospitalized for 3.50 ± 10.21 days in the NICUs and 6.1 ± 5.27 days in the neonatal wards. In total, 3.4% of the infants presented with SNHL. No significant difference was found between SNHL and neonates' age (P = 0.52), sex (P = 0.5), or sepsis (P = 0.94). However, SNHL was significantly associated with gestational age (P = 0.045), birth weight (P < 0.001), length of hospital stay (P < 0.001), pathological jaundice (P=0.033), antibiotic treatments (P = 0.007), and total serum bilirubin level (P = 0.01). Additionally, binary logistic regression analysis demonstrated the association between SNHL and these factors.
CONCLUSIONS
In this study, the prevalence of SNHL among hospitalized neonates was similar to previous reports in Iran and other countries. Based on the findings, administration of ototoxic drugs during the neonatal period can lead to SNHL. Therefore, it seems essential to regularly screen newborns under treatment and limit the indiscriminate use of ototoxic drugs.
背景
听力障碍是最常见的出生缺陷之一，是一种对言语和认知发展有负面影响的隐性残疾。
目的
本研究旨在评估伊朗戈尔甘医科大学附属教学医院新生儿重症监护病房（NICUs）和新生儿病房收治的婴儿中感音神经性听力损失（SNHL）的患病率，并确定相关危险因素。
患者与方法
在这项横断面研究中，通过非随机抽样招募了791名婴儿。收集受试者的人口统计学和临床特征，并在入院时进行自动听性脑干反应（AABR）测试。之后，对受试者进行随访并使用AABR测试重新评估。对于AABR结果异常的婴儿，在出院当天进行听性脑干反应（ABR）测试。
结果
婴儿入院时的平均年龄为3.75±4.86天，56.4%的受试者为女性。平均住院时间为9.63±1.1天；受试者在NICUs住院3.50±10.21天，在新生儿病房住院6.1±5.27天。共有3.4%的婴儿出现SNHL。SNHL与新生儿年龄（P = 0.52）、性别（P = 0.5）或败血症（P = 0.94）之间未发现显著差异。然而，SNHL与胎龄（P = 0.045）、出生体重（P < 0.001）、住院时间（P < 0.001）、病理性黄疸（P = 0.033）、抗生素治疗（P = 0.007）和总血清胆红素水平（P = 0.01）显著相关。此外，二元逻辑回归分析表明SNHL与这些因素之间存在关联。
结论
在本研究中，住院新生儿中SNHL的患病率与伊朗和其他国家以前的报告相似。基于这些发现，新生儿期使用耳毒性药物可导致SNHL。因此，似乎有必要对接受治疗的新生儿进行定期筛查，并限制耳毒性药物的滥用。
Zotero 插件