Department of Otorhinolaryngology, Sophia Children's Hospital, Erasmus Medical Center, Dr. Molewaterplein 60, SP-1455, 3015 GJ, Rotterdam, The Netherlands.
Eur Arch Otorhinolaryngol. 2011 Apr;268(4):501-5. doi: 10.1007/s00405-010-1415-8. Epub 2010 Nov 11.
Infants admitted to neonatal intensive care units (NICUs) have a higher incidence of perinatal complications and delayed maturational processes. Parameters of the auditory brainstem response (ABR) were analyzed to study the prevalence of delayed auditory maturation or neural pathology. The prevalence of prolonged I-V interval as a measure of delayed maturation and the correlation with ABR thresholds were investigated. All infants admitted to the NICU Sophia Children's Hospital between 2004 and 2009 who had been referred for ABR measurement after failing neonatal hearing screening with automated auditory brainstem response (AABR) were included. The ABR parameters were retrospectively analyzed. Between 2004 and 2009, 103 infants were included: 46 girls and 57 boys. In 58.3% (60 infants) of our population, the I-V interval was recordable in at least one ear at first diagnostic ABR measurement. In 4.9%, the I-V interval was severely prolonged. The median ABR threshold of infants with a normal or mildly prolonged I-V interval was 50 dB. The median ABR threshold of infants with a severely prolonged I-V interval was 30 dB. In conclusion, in case both peak I and V were measurable, we found only a limited (4.9%) incidence of severely prolonged I-V interval (≥0.8 ms) in this high-risk NICU population. A mild delay in maturation is a more probable explanation than major audiologic or neural pathology, as ABR thresholds were near normal in these infants.
新生儿重症监护病房（NICU）收治的婴儿围产期并发症和发育延迟的发生率较高。分析听觉脑干反应（ABR）的参数，以研究听觉成熟延迟或神经病理学的患病率。研究了作为成熟延迟指标的 I-V 间隔延长的患病率，以及与 ABR 阈值的相关性。所有 2004 年至 2009 年期间在 Sophia 儿童医院 NICU 住院，并在新生儿自动听觉脑干反应（AABR）听力筛查失败后被转介进行 ABR 测量的婴儿均被纳入研究。对 ABR 参数进行了回顾性分析。2004 年至 2009 年间，共纳入 103 例婴儿：46 例女孩，57 例男孩。在我们的研究人群中，58.3%（60 例）至少有一耳在首次诊断性 ABR 测量时可记录到 I-V 间隔。4.9%的婴儿 I-V 间隔严重延长。I-V 间隔正常或轻度延长的婴儿的 ABR 阈值中位数为 50dB。I-V 间隔严重延长的婴儿的 ABR 阈值中位数为 30dB。总之，在峰 I 和 V 均可测量的情况下，我们发现这种高危 NICU 人群中严重延长的 I-V 间隔（≥0.8ms）发生率仅有限（4.9%）。与主要的听觉或神经病理学相比，成熟的轻度延迟更有可能是解释，因为这些婴儿的 ABR 阈值接近正常。
