Gluckman E, Socie G, Yver A, Esperou H, Devergie A, Stern A
Bone Marrow Transplant Unit, Hôpital Saint Louis, Paris, France.
Bone Marrow Transplant. 1989 Sep;4(5):591-2.
Treatment with GM-CSF or G-CSF is becoming widely used in patients with chronic neutropenia, or who are aplastic following chemotherapy or autologous or allogeneic bone marrow transplantation. Recently, some authors have described a phenomenon analogous to cyclic agranulocytosis following treatment with G-CSF in a patient with chronic neutropenia. We wish to describe the same phenomenon in a patient with chronic granulocytic leukemia who received GM-CSF (Sandoz) after T cell depletion in order to accelerate hematological reconstitution.