非裔美国和白人中年女性的心理健康与颈动脉内膜中层厚度的关联
Associations of Psychological Well-Being With Carotid Intima Media Thickness in African American and White Middle-Aged Women.
作者信息
Shahabi Leila, Karavolos Kelly, Everson-Rose Susan A, Lewis Tené T, Matthews Karen A, Sutton-Tyrrell Kim, Powell Lynda H
机构信息
From the Department of Medicine (Shahabi), University of California, Los Angeles, Los Angeles, California; Department of Preventive Medicine (Karavolos, Powell), Rush University Medical Center, Chicago, Illinois; Department of Medicine (Everson-Rose), University of Minnesota, Minneapolis, Minnesota; Department of Epidemiology (Lewis), Rollins School of Public Health, Emory University, Atlanta, Georgia; Departments of Psychiatry (Matthews) and Epidemiology (Sutton-Tyrrell), University of Pittsburgh, Pittsburgh, Pennsylvania. Dr. Sutton-Tyrrell is deceased.
出版信息
Psychosom Med. 2016 May;78(4):511-9. doi: 10.1097/PSY.0000000000000293.
OBJECTIVES
The present cross-sectional study aimed to a) examine associations between measures of psychological well-being, specifically life satisfaction and life engagement, and intima media thickness, a subclinical marker of atherosclerosis; b) investigate if the interaction of psychological well-being and life events correlated with intima media thickness; and c) explore these relationships across race.
METHODS
A sample of 485 women (38% African American and 62% white; mean [standard deviation] age = 50.2 [2.9] years) underwent ultrasonography to assess carotid artery intima media thickness (IMT). The women completed self-report measures of life satisfaction, life engagement, and life events.
RESULTS
Average (standard deviation) IMT was 0.666 (0.10) mm. Life satisfaction showed a significant, independent, inverse relationship with IMT, after controlling for demographic, behavioral, psychological, and cardiovascular covariates (β = -0.105, p = .039), such that each 1-point higher life satisfaction score was correlated with a significant 0.008-mm lower level of mean IMT. No significant association was seen between life events and IMT (r = 0.05, p = .32), and life satisfaction did not interact with life events on IMT (β = -0.036, p = .46). No significant interaction between life satisfaction and race on IMT was observed (β = 0.068, p = .37). In contrast to life satisfaction, life engagement was not a significant correlate of IMT (r = -0.07, p = .12).
CONCLUSIONS
Life satisfaction, a measure of psychological well-being, is an important independent correlate of subclinical atherosclerosis in middle-aged women.
目的
本横断面研究旨在：a）研究心理健康指标，特别是生活满意度和生活投入度，与动脉粥样硬化的亚临床标志物内膜中层厚度之间的关联；b）调查心理健康与生活事件的相互作用是否与内膜中层厚度相关；c）探讨不同种族间的这些关系。
方法
对485名女性（38%为非裔美国人，62%为白人；平均[标准差]年龄 = 50.2[2.9]岁）进行超声检查，以评估颈动脉内膜中层厚度（IMT）。这些女性完成了关于生活满意度、生活投入度和生活事件的自我报告测量。
结果
平均（标准差）IMT为0.666（0.10）mm。在控制了人口统计学、行为、心理和心血管协变量后，生活满意度与IMT呈现显著、独立的负相关（β = -0.105，p = .039），即生活满意度得分每提高1分，平均IMT水平显著降低0.008mm。未发现生活事件与IMT之间存在显著关联（r = 0.05，p = .32），且生活满意度与生活事件对IMT没有相互作用（β = -0.036，p = .46）。未观察到生活满意度与种族在IMT上存在显著相互作用（β = 0.068，p = .37）。与生活满意度不同，生活投入度与IMT无显著相关性（r = -0.07，p = .12）。
结论
生活满意度作为心理健康的一项指标，是中年女性亚临床动脉粥样硬化的重要独立相关因素。
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