白色念珠菌中的外排体与极化分泌和丝状化有关。
The exocyst in Candida albicans polarized secretion and filamentation.
作者信息
Chavez-Dozal Alba A, Bernardo Stella M, Lee Samuel A
机构信息
Section of Infectious Diseases, New Mexico VA Healthcare System, 1501 San Pedro SE, Mail Code 111-J, Albuquerque, NM, 87108, USA.
Division of Infectious Diseases, University of New Mexico Health Science Center, Albuquerque, NM, 87131, USA.
出版信息
Curr Genet. 2016 May;62(2):343-6. doi: 10.1007/s00294-015-0553-3. Epub 2016 Jan 13.
The exocyst is an octameric complex that orchestrates the docking and tethering of vesicles to the plasma membrane during exocytosis and is fundamental for key biological processes including growth and establishment of cell polarity. Although components of the exocyst are well conserved among fungi, the specific functions of each component of the exocyst complex unique to Candida albicans biology and pathogenesis are not fully understood. This commentary describes recent findings regarding the role of exocyst subunits Sec6 and Sec15 in C. albicans filamentation and virulence.
外泌体是一种八聚体复合物，在胞吐过程中协调囊泡与质膜的对接和拴系，对于包括细胞极性的生长和建立在内的关键生物学过程至关重要。尽管外泌体的组成成分在真菌中高度保守，但白色念珠菌生物学和发病机制所特有的外泌体复合物各成分的具体功能尚未完全明确。本述评描述了关于外泌体亚基Sec6和Sec15在白色念珠菌丝状化和毒力方面作用的最新研究结果。
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