Uyama E, Katahira T, Okada H, Hashimoto Y, Araki S
Rinsho Shinkeigaku. 1989 May;29(5):617-21.
Two cases of progressive supranuclear palsy (PSP) with palilalia were presented. Case 1: A 64-year-old woman was in good health until age 62 when she noted clumsiness in walking. Subsequently, forgetfulness, abrupt falls and difficulty in swallowing developed. At the age of 63, she tended to repeat same words in conversation. On admission, neurological examination revealed mental deterioration (Hasegawa's scale 19), unsteady emotional state, supranuclear vertical gaze palsy, pseudobulbar palsy, nuchal dystonia, pyramidal tract signs and extrapyramidal signs. Although spontaneous speech production was reduced, she could answer to questions with compulsive repetition of a phrase or word. She always repeated twice or three times without stuttering, logoclonus or "palilalie aphone". Case 2: A 68-year-old, right-handed woman noted double vision since about one year ago. Subsequently, she developed slowness of voluntary movement, forgetfulness and difficulty in walking. Neurological examination showed similar signs as Case 1. She was not palilaic on examination, however we found the description of her palilalia on nurse's working records. Palilalia was not present so constantly as Case 1, but continued for about a year. We suppose that palilalia is not a rare phenomenon in PSP. Although the pathogenesis of palilalia is unknown at present, we speculate the combination of extrapyramidal sign, pseudobulbar palsy and dementia may most contribute the pathogenesis of palilalia on PSP.
报告了2例伴有复述言语的进行性核上性麻痹（PSP）病例。病例1：一名64岁女性，62岁前身体健康，此后出现行走笨拙。随后出现健忘、突然跌倒及吞咽困难。63岁时，她在交谈中倾向于重复相同的词语。入院时，神经学检查显示精神衰退（长谷川量表评分为19分）、情绪状态不稳定、核上性垂直凝视麻痹、假性延髓麻痹、颈部肌张力障碍、锥体束征和锥体外系征。尽管自发言语减少，但她能通过强迫性重复短语或单词来回答问题。她总是重复两三次，无口吃、言语痉挛或“无声复述言语”。病例2：一名68岁右利手女性，约1年前开始出现复视。随后，她出现随意运动迟缓、健忘及行走困难。神经学检查显示与病例1相似的体征。检查时她无复述言语，但我们在护士工作记录中发现了她复述言语的描述。她的复述言语不像病例1那样持续存在，但持续了约1年。我们认为复述言语在PSP中并非罕见现象。尽管目前复述言语的发病机制尚不清楚，但我们推测锥体外系征、假性延髓麻痹和痴呆的组合可能对PSP中复述言语的发病机制起主要作用。
