Wei Liming, Zhu Yueqi, Liu Fang, Zhang Peilei, Li Xiaocong, Zhao Jungong, Lu Haitao
Department of Diagnostic and Interventional Radiology Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, Shanghai 200233, China.
Department of Endocrinology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yi Shan Road, Shanghai 200233, China.
J Vasc Interv Radiol. 2016 Mar;27(3):322-9. doi: 10.1016/j.jvir.2015.11.025. Epub 2016 Jan 4.
To investigate factors predictive of thromboembolic occlusions and evaluate the efficacy of percutaneous aspiration thrombectomy (PAT) for infrainguinal thromboembolic occlusions in patients undergoing endovascular recanalization (EVR).
In this single-center retrospective study, 23 patients who underwent PAT for thromboembolism during EVR and 237 patients who underwent successful EVR without thromboembolic occlusions (control group) were enrolled. Immediate posttreatment and follow-up outcomes between groups were compared. Multivariate analysis was performed to identify factors predictive of thromboembolic occlusions. Technical success of PAT was defined as achievement of < 30% residual stenosis and restoration of modified thrombolysis in myocardial infarction grade 3 flow.
The technical success rate was 95.7% in the PAT group. After intervention, ankle brachial index (ABI), restoration of blood flow, and improvement in dorsal/plantar arterial pulse score showed no significant differences between the PAT and control groups. During follow-up, no significant differences were observed between groups in improvement of sustained ABI and maximum walking distance, ulcer healing, restenosis/occlusion and limb salvage rates, and pain relief in patients with critical ischemia. Stenosis greater than 90% with lesion occlusion (odds ratio, 12.891; 95% confidence interval, 1.676-99.161; P = .014) and intraluminal angioplasty (odds ratio, 18.423; 95% confidence interval, 2.408-140.942; P = .005) were associated with a high incidence of thromboembolism.
Stenosis greater than 90% with lesion occlusion and intraluminal angioplasty may be factors predictive of thromboembolic occlusions. PAT is a safe and effective treatment for thromboembolism during infrainguinal arterial EVR.
研究预测血栓栓塞性闭塞的因素,并评估经皮抽吸血栓切除术(PAT)对接受血管内再通术(EVR)的患者下肢血栓栓塞性闭塞的疗效。
在这项单中心回顾性研究中,纳入了23例在EVR期间因血栓栓塞接受PAT的患者以及237例成功进行EVR且无血栓栓塞性闭塞的患者(对照组)。比较两组治疗后即刻及随访结果。进行多因素分析以确定预测血栓栓塞性闭塞的因素。PAT的技术成功定义为残余狭窄<30%且恢复心肌梗死溶栓分级3级血流。
PAT组的技术成功率为95.7%。干预后,PAT组与对照组之间的踝肱指数(ABI)、血流恢复以及背/足底动脉搏动评分改善情况无显著差异。随访期间,两组在持续ABI改善、最大步行距离、溃疡愈合、再狭窄/闭塞及肢体挽救率以及严重缺血患者的疼痛缓解方面无显著差异。病变闭塞且狭窄大于90%(比值比,12.891;95%置信区间,1.676 - 99.161;P = 0.014)和腔内血管成形术(比值比,18.423;95%置信区间,2.408 - 140.942;P = 0.005)与血栓栓塞的高发生率相关。
病变闭塞且狭窄大于90%以及腔内血管成形术可能是血栓栓塞性闭塞的预测因素。PAT是治疗下肢动脉EVR期间血栓栓塞的一种安全有效的方法。