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踝下血管成形术和支架置入术治疗肢体挽救:解剖学考虑因素和长期结果。

Below-the-ankle angioplasty and stenting for limb salvage: anatomical considerations and long-term outcomes.

机构信息

Department of Interventional Radiology, School of Medicine, Patras University Hospital, 26504, Rion, Greece.

出版信息

Cardiovasc Intervent Radiol. 2013 Aug;36(4):926-35. doi: 10.1007/s00270-012-0514-x. Epub 2012 Nov 14.

Abstract

PURPOSE

To report the long-term angiographic and clinical results in a series of below-the-ankle (BTA) angioplasty procedures and to present some biomechanical issues related to the unique anatomical geometry of the ankle.

METHODS

We performed a retrospective analysis of BTA angioplasty procedures. Clinical end points included technical success, patient mortality, salvage of the treated foot, and repeat target lesion revascularization. Imaging end points included primary patency, binary restenosis of the target lesion at the 50% threshold, and stent integrity (stent fracture, deformation, or collapse). Univariate subgroup analysis was performed.

RESULTS

In total, 40 limbs in 37 patients (age 73.5 ± 8.2 years) with critical limb ischemia were included and 42 inframalleolar lesions (4.2 ± 1.4 cm) were analyzed. Technical success was achieved in 95.2% (40 of 42). Provisional stent placement was performed in 45.2% (19 of 42). Two patients died, and two major amputations occurred up to 3 years. At 1 year, overall primary vessel patency was 50.4 ± 9.1%, lesion binary restenosis rate was 64.1 ± 8.3%, and repeat intervention-free survival was 93.6 ± 4.3% according to life table analysis of all treated lesions. Pairwise subgroup analysis showed that BTA self-expanding stents were associated with significantly higher restenosis and poorer primary patency compared to plain balloon angioplasty or sirolimus-eluting balloon-expandable stents. Significant deformation and/or fracture of balloon-expandable stents placed BTA were identified in five of 11. Dynamic imaging showed that the dorsalis pedis artery is kinked during foot dorsiflexion, whereas the distal posterior tibial artery is kinked during plantar flexion of the foot.

CONCLUSION

BTA angioplasty for critical limb ischemia treatment is safe and feasible with satisfactory long-term results. BTA stent placement must be reserved for bailout indications.

摘要

目的

报告一系列踝下(BTA)血管成形术的长期血管造影和临床结果,并介绍与踝关节独特解剖结构相关的一些生物力学问题。

方法

我们对 BTA 血管成形术进行了回顾性分析。临床终点包括技术成功率、患者死亡率、治疗足部的挽救率和重复目标病变血运重建。影像学终点包括初次通畅率、目标病变 50%狭窄的二元再狭窄率和支架完整性(支架断裂、变形或塌陷)。进行了单变量亚组分析。

结果

共纳入 37 例(年龄 73.5±8.2 岁)严重肢体缺血患者的 40 条肢体和 42 个踝下病变(4.2±1.4cm)。技术成功率为 95.2%(40/42)。临时支架置入率为 45.2%(42/42)。2 例患者死亡,2 例患者在 3 年内发生大截肢。根据所有治疗病变的寿命表分析,1 年时总初始血管通畅率为 50.4%±9.1%,病变二元再狭窄率为 64.1%±8.3%,重复介入无事件生存率为 93.6%±4.3%。两两亚组分析显示,与单纯球囊血管成形术或西罗莫司洗脱球囊扩张支架相比,BTA 自膨式支架与更高的再狭窄率和较差的初始通畅率相关。11 个 BTA 中,有 5 个球囊扩张支架出现明显变形和/或断裂。动态影像学显示,足背屈时,足背动脉呈扭曲状,而足底屈时,后胫动脉呈扭曲状。

结论

BTA 血管成形术治疗严重肢体缺血安全可行,长期效果满意。BTA 支架置入必须保留用于紧急情况。

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