Coombs John R, Morken James P
Department of Chemistry, Boston College, Merkert Research Labs, 2609 Beacon St., Chesnut Hill, MA, 02467, USA.
Angew Chem Int Ed Engl. 2016 Feb 18;55(8):2636-49. doi: 10.1002/anie.201507151. Epub 2016 Jan 13.
Terminal alkenes are readily available functional groups which appear in α-olefins produced by the chemical industry, and they appear in the products of many contemporary synthetic reactions. While the organic transformations that apply to alkenes are amongst the most studied reactions in all of chemical synthesis, the number of reactions that apply to nonactivated terminal alkenes in a catalytic enantioselective fashion is small in number. This Minireview highlights the cases where stereocontrol in catalytic reactions of 1-alkenes is high enough to be useful for asymmetric synthesis.
末端烯烃是易于获得的官能团，它们存在于化学工业生产的α-烯烃中，并且出现在许多当代合成反应的产物中。虽然适用于烯烃的有机转化是所有化学合成中研究最多的反应之一，但以催化对映选择性方式应用于未活化末端烯烃的反应数量却很少。本综述着重介绍了1-烯烃催化反应中的立体控制程度高到足以用于不对称合成的情况。
