Pritze S, Alvarenga A E, Leguizamon O, Haubitz I
Armauer-Hansen-Institut, Würzburg, FRG.
Chemotherapy. 1989;35(5):373-82. doi: 10.1159/000238698.
In Paraguay, the National Leprosy/Tuberculosis Program is based on a combined chemotherapy with isoprodian and rifampicin. The aim of this descriptive study was to investigate the therapy durations used so far in the treatment of 475 leprosy patients and to analyze the criteria responsible for the wide-ranging differences in therapy durations. As initial criteria, the following parameters were identified to have a significant influence on the therapy duration: Patients never treated before or pretreated, clinical classification and initial bacteriological index (BI) value. During therapy, conditions like the attendance and BI decrease/year showed a significant correlation with the therapy duration. Even though the studied criteria did not allow to draw a definite conclusion with regard to an 'ideal' therapy duration, they proved to be reliable, as only 2 patients have relapsed so far.
在巴拉圭，国家麻风病/结核病项目采用异烟肼和利福平联合化疗。这项描述性研究的目的是调查迄今为止用于治疗475例麻风病患者的治疗疗程，并分析导致治疗疗程存在广泛差异的标准。作为初始标准，确定以下参数对治疗疗程有显著影响：从未接受过治疗或曾接受过预处理的患者、临床分类和初始细菌学指数（BI）值。在治疗期间，诸如就诊情况和BI每年下降幅度等情况与治疗疗程显示出显著相关性。尽管所研究的标准无法就“理想”治疗疗程得出明确结论，但它们被证明是可靠的，因为迄今为止仅有2例患者复发。
