Wong M M C, Chan C F, Li S W, Lau Y M
Department of Psychiatry, United Christian Hospital, Kwun Tong, Hong Kong SAR, China.
Castle Peak Hospital, 1/F, Block F, Tuen Mun, Hong Kong SAR, China.
East Asian Arch Psychiatry. 2015 Dec;25(4):146-9.
To assess cognitive performance in elderly depressed patients following treatment for 6 months. Remission rate of depression after 6 months of treatment was calculated.
The study was performed in a consecutive group of patients aged ≥ 65 years with late-onset depression. Severity of depression was assessed by the Hamilton Depression Scale, cognitive performance by the Hong Kong Montreal Cognitive Assessment, and functional level by the Instrumental Activities of Daily Living Scale.
A total of 52 patients were recruited. In all, 28 (53.8%) were found to have cognitive impairment at baseline and 8 (28.6%) of them had improvement after 6 months. This cognitively impaired group was older and had a lower Instrumental Activities of Daily Living Scale score. The remission rate of depression was 61.5%.
Cognitive impairment constituted a stable feature in a considerable number of elderly patients with depression. About two-thirds of patients achieved remission of depression after 6 months of treatment.
评估老年抑郁症患者治疗6个月后的认知表现。计算治疗6个月后的抑郁症缓解率。
本研究纳入了一组连续的年龄≥65岁的迟发性抑郁症患者。采用汉密尔顿抑郁量表评估抑郁严重程度，采用香港蒙特利尔认知评估量表评估认知表现，采用日常生活活动能力量表评估功能水平。
共招募了52名患者。总体而言，28名（53.8%）患者在基线时被发现存在认知障碍，其中8名（28.6%）在6个月后有所改善。该认知障碍组年龄更大，日常生活活动能力量表得分更低。抑郁症缓解率为61.5%。
认知障碍是相当一部分老年抑郁症患者的一个稳定特征。约三分之二的患者在治疗6个月后实现了抑郁症缓解。
