Gaynor E R, Fisher R I
Loyola University Stritch School of Medicine, Section of Hematology/Oncology, Maywood, Illinois.
Dis Mon. 1989 Sep;35(9):597-650.
The non-Hodgkin's lymphomas are a diverse group of diseases with distinctive natural histories and responsiveness to therapy. Each of these diseases represents the arrest and proliferation of malignant lymphocytes at a particular stage of normal lymphocyte differentiation. Cytogenetic and gene rearrangement studies have established the clonal nature of these disorders. The majority of the non-Hodgkin's lymphomas that occur in adults are of B cell origin. Exceptions to this are lymphoblastic lymphoma, mycosis fungoides, Sézary syndrome, and HTLV-1 associated leukemia--lymphomas that are diseases of T cell origin. As a group, the non-Hodgkin's lymphomas are diseases that are very responsive to radiation therapy and chemotherapy. There are major differences, however, in the durability of these responses. From a clinical standpoint, the non-Hodgkin's lymphomas may be divided into those that are indolent and those that are aggressive in their clinical behavior. Ironically, the aggressive non-Hodgkin's lymphomas are frequently curable, while the indolent non-Hodgkin's lymphomas are presently incurable in the majority of cases.
非霍奇金淋巴瘤是一组具有独特自然病程和对治疗反应性的多种疾病。这些疾病中的每一种都代表了恶性淋巴细胞在正常淋巴细胞分化的特定阶段的停滞和增殖。细胞遗传学和基因重排研究已证实这些疾病的克隆性质。大多数发生在成人中的非霍奇金淋巴瘤起源于B细胞。例外情况是淋巴母细胞淋巴瘤、蕈样霉菌病、塞扎里综合征以及HTLV-1相关白血病——淋巴瘤，它们是起源于T细胞的疾病。作为一个整体，非霍奇金淋巴瘤是对放射治疗和化学治疗非常敏感的疾病。然而，这些反应的持久性存在重大差异。从临床角度来看，非霍奇金淋巴瘤可分为临床行为惰性的和侵袭性的。具有讽刺意味的是，侵袭性非霍奇金淋巴瘤常常可以治愈，而惰性非霍奇金淋巴瘤在大多数情况下目前无法治愈。
