Sandvik Reidun, Selbaek Geir, Kirkevold Oyvind, Aarsland Dag, Husebo Bettina Sandgathe
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
National Advisory Unit on Ageing and Health, Oslo Universitetssykehus HF, Oslo, Norway.
Age Ageing. 2016 Jan;45(1):54-60. doi: 10.1093/ageing/afv184.
the analgesic drug use has been reported to increase in general in nursing home patients. However, there is insufficient evidence in terms of what agents are used, variations of use over time and to whom these drugs are prescribed.
we investigated the prescribing patterns of scheduled analgesic drugs in Norwegian nursing home patients from 2000 to 2011, with the association to age, gender, cognitive function and type of nursing home unit.
secondary analyses of four study samples (three observational studies and one randomised controlled trial).
nursing home patients included in study samples from 2000 (n = 1,926), 2004 (n = 1,163), 2009 (n = 850) and 2011 (n = 1,858) located in 14 Norwegian counties.
trend analyses of analgesic drug prescriptions. Percentages were described using t-test, χ(2) and Mann-Whitney U test and multivariate logistic regression.
the odds ratio for receiving any pain medication in 2011 compared with 2000 was 2.6 (95% CI 2.23-2.91), this is corresponding to a 65% increase from 34.9 to 57.6%. The paracetamol prescription increased by 113%, from 22.7% in 2000 to 48.4% in 2011. Strong opioids (fentanyl, buprenorphine, morphine, oxycodone) increased from 1.9% in 2000 to 17.9% in 2011 (P < 0.001), whereas non-steroidal anti-inflammatory drug prescription decreased, from 6.8 to 3.2%. In 2000, 2004 and 2009, people with dementia received fewer analgesics compared with patients without dementia; no differences in analgesic drug use between the groups were found in 2011.
the analgesic drug prescription increased significantly from 2000 to 2011, especially the use of paracetamol and strong opioids. We also highlight a possible change from under-prescription of analgesic medication in people with dementia, to an equal amount compared with patients without cognitive impairment.
据报道,疗养院患者的镇痛药总体使用量有所增加。然而,关于使用了哪些药物、随时间的使用变化情况以及这些药物是开给哪些人的,证据并不充分。
我们调查了2000年至2011年挪威疗养院患者中常规镇痛药的处方模式,以及与年龄、性别、认知功能和疗养院单元类型的关联。
对四个研究样本(三项观察性研究和一项随机对照试验)进行二次分析。
研究样本中的疗养院患者来自2000年(n = 1926)、2004年(n = 1163)、2009年(n = 850)和2011年(n = 1858),分布在挪威的14个郡。
镇痛药处方的趋势分析。使用t检验、χ²检验、Mann-Whitney U检验和多因素逻辑回归来描述百分比。
与2000年相比,2011年接受任何止痛药治疗的比值比为2.6(95%可信区间2.23 - 2.91),这相当于从34.9%增加到57.6%,增长了65%。对乙酰氨基酚的处方量增加了113%,从2000年的22.7%增至2011年的48.4%。强效阿片类药物(芬太尼、丁丙诺啡、吗啡、羟考酮)从2000年的1.9%增至2011年的17.9%(P < 0.001),而非甾体抗炎药的处方量则从6.8%降至3.2%。在2000年、2004年和200年,与无痴呆症患者相比,痴呆症患者接受的镇痛药较少;2011年两组之间在镇痛药使用上未发现差异。
从2000年到2011年,镇痛药处方显著增加,尤其是对乙酰氨基酚和强效阿片类药物的使用。我们还强调了一个可能的变化,即从对痴呆症患者镇痛药处方不足,转变为与无认知障碍患者使用量相当。