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先发制人避免策略(P.E.A.S.)——应对儿科人群中的过敏性接触性皮炎

Pre-Emptive Avoidance Strategy (P.E.A.S.) - addressing allergic contact dermatitis in pediatric populations.

作者信息

Hill Hannah, Goldenberg Alina, Golkar Linda, Beck Kristyn, Williams Judith, Jacob Sharon E

机构信息

a School of medicine , Loma Linda University , Loma Linda , CA , USA.

b Preliminary Internal Medicine and Dermatology , San Diego Medical Center, University of California , La Jolla , CA , USA.

出版信息

Expert Rev Clin Immunol. 2016;12(5):551-61. doi: 10.1586/1744666X.2016.1142373. Epub 2016 Feb 29.

Abstract

Pediatric allergic contact dermatitis (ACD) has been increasingly recognized in the United States. Reported rates of positive patch tests in children referred for suspected ACD range between 27 and 95.6%. Many young children are becoming sensitized to contact allergens found in personal hygiene products. We reviewed five recent pediatric patch test studies to determine the top allergens associated with this source of ACD in children. The top ten allergens were neomycin, balsam of Peru, fragrance mix, lanolin, cocamidopropylbetaine, formaldehyde, corticosteroids, methylchlorisothiazolinone (MCI)/methylisothiazolinone (MI), propylene glycol, and benzalkonium chloride. We estimate that one third of children suffering from ACD could potentially benefit from a 'pre-emptive avoidance strategy' (P.E.A.S.) of the stated top 10 allergens.

摘要

在美国,儿童过敏性接触性皮炎(ACD)已越来越受到关注。疑似患有ACD的儿童中,斑贴试验阳性报告率在27%至95.6%之间。许多幼儿对个人卫生用品中的接触性过敏原变得敏感。我们回顾了五项近期的儿童斑贴试验研究,以确定与儿童这种来源的ACD相关的主要过敏原。前十位过敏原是新霉素、秘鲁香脂、香料混合物、羊毛脂、椰油酰胺丙基甜菜碱、甲醛、皮质类固醇、甲基氯异噻唑啉酮(MCI)/甲基异噻唑啉酮(MI)、丙二醇和苯扎氯铵。我们估计,三分之一患有ACD的儿童可能会从对上述前十位过敏原的“先发制人避免策略”(P.E.A.S.)中受益。

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