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美国常见高防晒系数广谱防晒霜的潜在致敏性;从自身免疫性皮肤病患者的角度来看。

Potential allergenicity of commonly sold high SPF broad spectrum sunscreens in the United States; from the perspective of patients with autoimmune skin disease.

作者信息

Keyes Emily, Werth Victoria P, Brod Bruce

机构信息

Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA.

Department of Dermatology, University of Pennsylvania, Philadelphia, PA.

出版信息

Int J Womens Dermatol. 2019 May 23;5(4):227-232. doi: 10.1016/j.ijwd.2019.05.006. eCollection 2019 Sep.

Abstract

BACKGROUND

Lack of established criteria for sunscreen product recommendations and potentially allergenic ingredients in sunscreens pose an issue for physicians and patients with autoimmune skin conditions.

OBJECTIVE

We reviewed popular sunscreens for effectiveness and potential allergenicity for recommendation and use in the autoimmune skin condition population.

METHODS

In this cohort study, we selected sunscreens from the bestseller lists of Amazon, Target, and CVS. Of those, sunscreens with sun protection factor of 50 to 99 and 100 that met our effectiveness criteria (52 sunscreens) were analyzed for allergenic ingredients. An allergen list was developed from the North American Contact Dermatitis Group core data and stratified into low-prevalence and high-prevalence allergens.

RESULTS

The allergenicity of popular sunscreens that met our effectiveness criteria are organized in a table by number of tiered potential allergens. Although no sunscreen was allergen-free, several products contained a minimal number of low-prevalence allergens. The most common low-prevalence allergens were chemical sunscreen ingredients avobenzone, octocrylene, and oxybenzone, and the most common high-prevalence allergen was fragrance. A limitation is that not all U.S. sunscreens were analyzed.

CONCLUSION

With the wide range of sunscreens available, physicians and patients should be aware of the effectiveness and potential allergenicity of sunscreens and make recommendations and consumption choices accordingly.

摘要

背景

缺乏用于防晒产品推荐的既定标准以及防晒产品中潜在的致敏成分,这给患有自身免疫性皮肤病的医生和患者带来了问题。

目的

我们评估了热门防晒产品的有效性和潜在致敏性,以便为自身免疫性皮肤病患者群体提供推荐和使用建议。

方法

在这项队列研究中,我们从亚马逊、塔吉特和CVS的畅销榜单中挑选防晒产品。其中,对防晒系数为50至99以及100且符合我们有效性标准的防晒产品(52种防晒产品)进行致敏成分分析。根据北美接触性皮炎小组的核心数据制定了一份过敏原清单,并将其分为低流行率和高流行率过敏原。

结果

符合我们有效性标准的热门防晒产品的致敏性按潜在过敏原分级数量列于表格中。虽然没有一款防晒产品完全无过敏原,但有几款产品所含的低流行率过敏原数量极少。最常见的低流行率过敏原是化学防晒成分阿伏苯宗、奥克立林和氧苯酮,最常见的高流行率过敏原是香料。一个局限性是未对所有美国防晒产品进行分析。

结论

鉴于有各种各样的防晒产品可供选择,医生和患者应了解防晒产品的有效性和潜在致敏性,并据此做出推荐和消费选择。

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