在给予0.4%酮咯酸和0.1%奈帕芬胺的健康兔眼中房水和玻璃体液的前列腺素E水平
Prostaglandin E Levels of Aqueous and Vitreous Humor in Ketorolac 0.4% and Nepafenac 0.1% Administered Healthy Rabbits.
作者信息
Acar Ugur, Acar Damla Erginturk, Tanriverdi Cafer, Acar Mutlu, Ozdemir Ozdemir, Erikci Acelya, Ornek Firdevs
机构信息
a Department of Ophthalmology , Hacettepe University, Faculty of Medicine , Ankara , Turkey.
b Department of Ophthalmology , Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
出版信息
Ocul Immunol Inflamm. 2017 Jun;25(3):323-327. doi: 10.3109/09273948.2015.1116587. Epub 2016 Jan 14.
PURPOSE
To compare the lowering effects of ketorolac 0.4% and nepafenac 0.1% on aqueous and vitreous humor prostaglandin E (PGE) levels in rabbits.
METHODS
Ketorolac and nepafenac ophthalmic solutions were administered to the right eyes of 24 healthy rabbits after randomized division into two groups. The left eyes of these rabbits were considered as controls for the two groups. On the 4th day of the experiment, the samples were taken from the aqueous and vitreous humors of the rabbits bilaterally, and PGE levels were measured by an enzyme immune assay kit.
RESULTS
Ketorolac and nepafenac achieved a statistically significant decrease (p<0.001, for each) in PGE levels in the aqueous (11.75 ± 6.15 and 14.75 ± 7.60 pg/mL, respectively) and the vitreous humor (6.58 ± 4.62 and 9.83 ± 4.55 pg/mL, respectively).
CONCLUSIONS
Both ketorolac and nepafenac inhibited PGE levels in both the aqueous and vitreous humors of rabbits. Although PGE-lowering effects were similar in the aqueous humor, nepafenac seemed to be more potent than ketorolac in the vitreous humor.
目的
比较0.4%酮咯酸和0.1%奈帕芬酸对兔眼房水和玻璃体液中前列腺素E（PGE）水平的降低作用。
方法
将24只健康兔随机分为两组，对其右眼分别给予酮咯酸和奈帕芬酸眼药水。这些兔子的左眼作为两组的对照。实验第4天，从兔子双侧眼的房水和玻璃体液中取样，用酶免疫分析试剂盒测定PGE水平。
结果
酮咯酸和奈帕芬酸均使房水（分别为11.75±6.15和14.75±7.60 pg/mL）和玻璃体液（分别为6.58±4.62和9.83±4.55 pg/mL）中的PGE水平出现统计学显著下降（每组p<0.001）。
结论
酮咯酸和奈帕芬酸均能抑制兔眼房水和玻璃体液中的PGE水平。虽然二者降低房水中PGE的作用相似，但在玻璃体液中，奈帕芬酸似乎比酮咯酸更有效。
Zotero 插件