新生儿腹部脂肪的影像学表现：糖尿病母亲所生婴儿的一个标志物。

Radiographic depiction of intra-abdominal fat in newborns: a marker of infants born to diabetic mothers.

作者信息

Ponrartana S, Goodarzian F, Emadi S, Aggabao P C, Fisher C L, Gilsanz V

机构信息

Department of Radiology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

出版信息

J Perinatol. 2016 May;36(5):389-91. doi: 10.1038/jp.2015.210. Epub 2016 Jan 14.

DOI:10.1038/jp.2015.210

PMID:26765553

Abstract

OBJECTIVE

To examine whether the presence of intra-abdominal fat (IAF) in newborns is diagnostic of infants of diabetic mothers (IDMs), and determine whether IAF is merely the consequence of increased body size.

STUDY DESIGN

Abdominal radiographs of 277 neonates >34 weeks gestational age (147 male and 130 female) were reviewed to determine the presence of IAF. Unpaired t-test and regression analyses were used to examine the influence of gestational age, birth weight, birth length and maternal diabetes on the prevalence and thickness of IAF.

RESULT

The prevalence of IAF was higher in IDMs (41.2% vs 13.2%; P<0.0001)-an association that persisted even after accounting for sex, gestational age and weight. Both birth weight and maternal diabetic status influenced the amount of IAF. Values of IAF thickness in IDMs were, however, more than threefold greater than those in non-IDMs (2.53±2.08 vs 0.81±0.29 mm; P<0.0001). An IAF thickness >1.5 mm was indicative of an IDM.

CONCLUSION

The depiction of IAF in radiographs is significantly more prevalent in IDMs when compared with non-IDMs, regardless of body size. A thickness of IAF >1.5 mm is a marker that should encourage work-up for the physiological, metabolic and congenital complications associated with IDM.

摘要

目的

研究新生儿腹内脂肪（IAF）的存在是否可用于诊断糖尿病母亲的婴儿（IDM），并确定IAF是否仅仅是体型增大的结果。

研究设计

回顾了277例孕龄>34周新生儿（147例男性和130例女性）的腹部X线片，以确定IAF的存在情况。采用非配对t检验和回归分析来研究孕龄、出生体重、出生身长和母亲糖尿病对IAF患病率和厚度的影响。

结果

IDM中IAF的患病率更高（41.2%对13.2%；P<0.0001）——即使在考虑了性别、孕龄和体重之后，这种关联仍然存在。出生体重和母亲糖尿病状态均影响IAF的量。然而，IDM中IAF厚度值比非IDM中的厚度值大三倍多（2.53±2.08对0.81±0.29毫米；P<0.0001）。IAF厚度>1.5毫米提示为IDM。