妊娠期糖尿病肥胖女性的新生儿肝内脂肪增加。
Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes.
机构信息
Department of Pediatrics, School of Medicine, University of Colorado Denver, Denver, CO, USA.
出版信息
J Pediatr. 2013 May;162(5):930-6.e1. doi: 10.1016/j.jpeds.2012.11.017. Epub 2012 Dec 20.
OBJECTIVES
To assess precision magnetic resonance imaging in the neonate and determine whether there is an early maternal influence on the pattern of neonatal fat deposition in the offspring of mothers with gestational diabetes mellitus (GDM) and obesity compared with the offspring of normal-weight women.
STUDY DESIGN
A total of 25 neonates born to normal weight mothers (n = 13) and to obese mothers with GDM (n = 12) underwent magnetic resonance imaging for the measurement of subcutaneous and intra-abdominal fat and magnetic resonance spectroscopy for the measurement of intrahepatocellular lipid (IHCL) fat at 1-3 weeks of age.
RESULTS
Infants born to obese/GDM mothers had a mean 68% increase in IHCL compared with infants born to normal-weight mothers. For all infants, IHCL correlated with maternal prepregnancy body mass index but not with subcutaneous adiposity.
CONCLUSION
Deposition of liver fat in the neonate correlates highly with maternal body mass index. This finding may have implications for understanding the developmental origins of childhood nonalcoholic fatty liver disease.
目的
评估新生儿精密磁共振成像，并确定与正常体重母亲所生婴儿相比，患有妊娠糖尿病（GDM）和肥胖的母亲所生婴儿的新生儿脂肪沉积模式是否存在早期的母体影响。
研究设计
共有 25 名新生儿接受磁共振成像，以测量皮下和腹内脂肪，同时进行磁共振光谱检查，以测量 1-3 周龄时的肝内细胞内脂质（IHCL）脂肪。这些新生儿分别来自于正常体重母亲（n=13）和肥胖合并 GDM 母亲（n=12）。
结果
与来自正常体重母亲的婴儿相比，来自肥胖/GDM 母亲的婴儿 IHCL 增加了 68%。对于所有婴儿，IHCL 与母亲孕前体重指数相关，但与皮下脂肪无关。
结论
新生儿肝脏脂肪沉积与母体体重指数密切相关。这一发现可能对理解儿童非酒精性脂肪肝的发育起源具有重要意义。
Zotero 插件