Leicht Christof A, Paulson Thomas A W, Goosey-Tolfrey Victoria L, Bishop Nicolette C
The Peter Harrison Centre for Disability Sport, School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, UNITED KINGDOM.
Med Sci Sports Exerc. 2016 Jun;48(6):1161-8. doi: 10.1249/MSS.0000000000000874.
The amount of active muscle mass can influence the acute inflammatory response to exercise, associated with reduced risk for chronic disease. This may affect those restricted to upper body exercise, for example, due to injury or disability. The purpose of this study was to compare the inflammatory responses for arm exercise and intensity-matched leg exercise.
Twelve male individuals performed three 45-min constant load exercise trials after determination of peak oxygen uptake for arm exercise (V˙O2peak A) and cycling (V˙O2peak C): 1) arm cranking exercise at 60% V˙O2peak A, 2) moderate cycling at 60% V˙O2peak C, and 3) easy cycling at 60% V˙O2peak A. Cytokine, adrenaline, and flow cytometric analysis of monocyte subsets were performed before and up to 4 h postexercise.
Plasma IL-6 increased from resting concentrations in all trials; however, postexercise concentrations were higher for arm exercise (1.73 ± 1.04 pg·mL) and moderate cycling (1.73 ± 0.95 pg·mL) compared with easy cycling (0.87 ± 0.41 pg·mL; P < 0.04). Similarly, the plasma IL-1ra concentration in the recovery period was higher for arm exercise (325 ± 139 pg·mL) and moderate cycling (316 ± 128 pg·mL) when compared with easy cycling (245 ± 77 pg·mL, P < 0.04). Arm exercise and moderate cycling induced larger increases in monocyte numbers and larger increases of the classical monocyte subset in the recovery period than easy cycling (P < 0.05). The postexercise adrenaline concentration was lowest for easy cycling (P = 0.04).
Arm exercise and cycling at the same relative exercise intensity induces a comparable acute inflammatory response; however, cycling at the same absolute oxygen uptake as arm exercise results in a blunted cytokine, monocyte, and adrenaline response. Relative exercise intensity appears to be more important to the acute inflammatory response than modality, which is of major relevance for populations restricted to upper body exercise.
活跃肌肉量可影响运动后的急性炎症反应，这与降低慢性病风险相关。例如，这可能会影响因受伤或残疾而只能进行上肢运动的人群。本研究的目的是比较手臂运动和强度匹配的腿部运动的炎症反应。
12名男性在确定手臂运动（V˙O2峰值A）和骑自行车（V˙O2峰值C）的峰值摄氧量后，进行了三次45分钟的恒定负荷运动试验：1）以60%V˙O2峰值A进行手臂曲柄运动，2）以60%V˙O2峰值C进行中等强度骑行，3）以60%V˙O2峰值A进行轻松骑行。在运动前和运动后长达4小时进行细胞因子、肾上腺素和单核细胞亚群的流式细胞术分析。
在所有试验中，血浆白细胞介素-6（IL-6）均从静息浓度升高；然而，与轻松骑行（0.87±0.41 pg·mL；P<0.04）相比，手臂运动（1.73±1.04 pg·mL）和中等强度骑行（1.73±0.95 pg·mL）后的浓度更高。同样，与轻松骑行（245±77 pg·mL，P<0.04）相比，手臂运动（325±139 pg·mL）和中等强度骑行（316±128 pg·mL）恢复期的血浆IL-1受体拮抗剂（IL-1ra）浓度更高。与轻松骑行相比，手臂运动和中等强度骑行在恢复期引起的单核细胞数量增加更大，经典单核细胞亚群增加更大（P<0.05）。轻松骑行后的运动后肾上腺素浓度最低（P=0.04）。
在相同相对运动强度下，手臂运动和骑行引起的急性炎症反应相当；然而，与手臂运动相同绝对摄氧量的骑行导致细胞因子、单核细胞和肾上腺素反应减弱。相对运动强度似乎比运动方式对急性炎症反应更重要，这对仅限于上肢运动的人群具有重要意义。
