Lidbury P S, Thiemermann C, Thomas G R, Vane J R
William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, U.K.
Eur J Pharmacol. 1989 Jul 18;166(2):335-8. doi: 10.1016/0014-2999(89)90079-4.
Endothelin-3 (1 nmol/kg) given i.v. to anaesthetised rabbits significantly inhibited ADP-induced ex vivo platelet aggregation, while causing only a transient decrease in blood pressure and no change in heart rate. Pretreatment with piroxicam (14 mumol/kg) abolished the anti-aggregatory effect. Thus, endothelin-3, while not inhibiting rabbit platelets in vitro, can induce the release of a cyclo-oxygenase produce, probably prostacyclin, which inhibits ex vivo aggregation. Unlike endothelin-1, this was achieved with minimal effect on the haemodynamics.
给麻醉的兔子静脉注射内皮素 -3（1纳摩尔/千克）可显著抑制二磷酸腺苷诱导的离体血小板聚集，同时仅引起血压短暂下降，心率无变化。用吡罗昔康（14微摩尔/千克）预处理可消除这种抗聚集作用。因此，内皮素 -3虽然在体外不抑制兔血小板，但可诱导环氧化酶产物（可能是前列环素）的释放，从而抑制离体血小板聚集。与内皮素 -1不同，这种作用对血流动力学的影响最小。
