大鼠的年龄、体重与减压病
Age, weight and decompression sickness in rats.
作者信息
Buzzacott Peter, Theron Michael, Mazur Aleksandra, Wang Qiong, Lambrechts Kate, Eftedal Ingrid, Ardestani Simin Berenji, Guerrero François
机构信息
a Laboratoire Optimisation des Régulations Physiologiques (ORPhy) , UFR Sciences et Techniques, Université de Bretagne Occidentale , Brest Cedex , France .
b The School of Sports Science, Exercise and Health, The University of Western Australia , Crawley , WA , Australia , and.
出版信息
Arch Physiol Biochem. 2016;122(2):67-9. doi: 10.3109/13813455.2016.1140787. Epub 2016 Mar 12.
OBJECTIVE
The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats.
METHODS
Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery, surviving rats were re-dived using the same compression-decompression profile.
RESULTS
In this experiment, there was a clear difference between DCS outcome at ages 11 or 13 weeks in matched rats (p = 0.002).
DISCUSSION
Even with weight included in the model, age was significantly associated with DCS (p = 0.01), yet after removal of weight the association was much stronger (p = 0.002).
CONCLUSION
We believe that age is likely to be found associated with the probability of DCS in a larger dataset with a wider range of parameters, after accounting for the effect of weight.
目的
本研究的目的是确定在控制体重后，年龄是否与大鼠减压病（DCS）相关。
方法
在压缩-减压后，观察11周龄雄性大鼠是否患减压病。恢复两周后，对存活的大鼠使用相同的压缩-减压方案再次进行潜水。
结果
在本实验中，匹配大鼠中11周龄和13周龄时减压病的结果存在明显差异（p = 0.002）。
讨论
即使在模型中纳入了体重因素，年龄仍与减压病显著相关（p = 0.01），但去除体重因素后，这种关联更强（p = 0.002）。
结论
我们认为，在考虑体重影响后，在参数范围更广的更大数据集中，可能会发现年龄与减压病的发生概率相关。
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