Bjerregaard Jon Kroll, Mortensen Michael Bau, Pfeiffer Per
a Department of Oncology , Odense University Hospital , Odense , Denmark ;
b Institute of Clinical Research, University of Southern Denmark , Odense , Denmark ;
Acta Oncol. 2016;55 Suppl 1:40-5. doi: 10.3109/0284186X.2015.1114675. Epub 2016 Jan 15.
Cancers of the liver, bile duct, gall bladder and pancreas (HPB-c) are a heterogeneous group, united almost exclusively by a poor prognosis. As the number of elderly in the Western world continues to rise and HPB-c are associated with age, we wanted to examine changes in incidence, mortality, prevalence and relative survival for these cancers.
HBP-c was defined as ICD-10 codes C22 (liver), C23-24 (gall bladder), and C25 (pancreas). Data derived from the NORDCAN database with comparable data on cancer incidence, mortality, prevalence and relative survival in the Nordic countries, where the Danish data were delivered from the Danish Cancer Registry and the Danish Cause of Death Registry with follow-up for death or emigration until the end of 2013.
The incidence and mortality rates of cancer of the liver and pancreas increased over time while the rates of cancer of the gall bladder and bile duct decreased. All HBP-c were more frequent in persons over the age of 70 than in younger persons. The relative one- and five-year survival rose in most HPB-c, but mainly occurring in the younger population of 0-69 years with only small to no gains in the 80 + group.
As the number of persons aged 80 years or more will increase dramatically in the following years, and our results show a gap in relative survival, it is important to continue to study this population in order to improve management and outcome.
肝脏、胆管、胆囊和胰腺癌（HPB癌）是一组异质性癌症，几乎仅因预后不良而被归为一类。随着西方世界老年人数量持续增加，且HPB癌与年龄相关，我们希望研究这些癌症在发病率、死亡率、患病率和相对生存率方面的变化。
HPB癌定义为国际疾病分类第十版（ICD - 10）编码C22（肝脏）、C23 - 24（胆囊）和C25（胰腺）。数据来源于北欧癌症登记数据库（NORDCAN），该数据库提供了北欧国家癌症发病率、死亡率、患病率和相对生存率的可比数据，其中丹麦数据来自丹麦癌症登记处和丹麦死因登记处，随访至2013年底的死亡或移民情况。
肝癌和胰腺癌的发病率和死亡率随时间上升，而胆囊癌和胆管癌的发病率和死亡率下降。所有HPB癌在70岁以上人群中比在较年轻人群中更常见。大多数HPB癌的1年和5年相对生存率有所上升，但主要发生在0 - 69岁的较年轻人群中，80岁及以上人群的生存率仅有小幅提高或没有提高。
鉴于80岁及以上人群数量在未来几年将大幅增加，且我们的结果显示了相对生存率方面的差距，继续研究这一人群以改善治疗管理和治疗结果很重要。
