Mutagenesis Unit, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.
Nanomedicine. 2016 May;12(4):1083-1093. doi: 10.1016/j.nano.2015.12.375. Epub 2016 Jan 6.
High grade gliomas (HGGs) are fatal brain tumors due to their infiltration capacity and the presence of resistant cell populations. Further, the brain is naturally protected from many exogenous molecules by the brain blood barrier (BBB), which limits or cancels passage of cytotoxic drugs to the tumor sites. In order to cope with the latter problem, nanoparticle (NP)-based carriers are intensively investigated, due to multiple possibilities to drive them across the BBB to the tumor sites and drop cytotoxic molecules there. The current status of research on NP for drug delivery to HGGs has been analyzed. The results indicate gold, lipids and proteins as three main materials featuring NP formulations for HGG treatment. Albeit specific drug targeting to HGG cells may have not been so far significantly improved, NP may help drugs crossing the BBB and enter the brain thus potentially fixing at least one part of the problem.
High grade gliomas (HGG) are very aggressive tumours and current therapy remains unsatisfactory. The advance in nanomedicine has allowed the development of novel treatment modalities. In this review article, the authors outlined the current status in using nanoparticle (NP)-based carriers for drug delivery to HGG. This should help readers to understand and develop ideas for further drug carrier designs.
高级别神经胶质瘤（HGG）是致命的脑肿瘤，因为它们具有浸润能力和存在耐药细胞群体。此外，大脑通过血脑屏障（BBB）自然受到许多外源性分子的保护，这限制或阻止细胞毒性药物进入肿瘤部位。为了解决后者的问题，纳米粒子（NP）载体正被深入研究，因为有多种可能性可以将其驱动穿过 BBB 到达肿瘤部位并在那里释放细胞毒性分子。本文分析了用于治疗 HGG 的 NP 药物输送的研究现状。结果表明，金、脂质和蛋白质是用于治疗 HGG 的 NP 制剂的三种主要材料。尽管针对 HGG 细胞的特定药物靶向作用迄今尚未得到显著改善，但 NP 可能有助于药物穿过 BBB 进入大脑，从而潜在地解决至少一部分问题。
高级别神经胶质瘤（HGG）是非常侵袭性的肿瘤，目前的治疗仍然不尽如人意。纳米医学的进步使得新的治疗方式得以发展。在这篇综述文章中，作者概述了目前使用纳米粒子（NP）载体进行 HGG 药物输送的现状。这应该有助于读者理解并为进一步的药物载体设计提供思路。
