Park Shin-Eui, Yang Jong-Chul, Jeong Gwang-Woo
1Interdisciplinary Program of Biomedical Engineering,Chonnam National University,Gwangju,Republic of Korea.
2Department of Psychiatry,Chonbuk National University Medical School,Jeonju,Republic of Korea.
Acta Neuropsychiatr. 2016 Aug;28(4):206-13. doi: 10.1017/neu.2015.63. Epub 2016 Jan 15.
We performed functional magnetic resonance imaging (fMRI) to discriminate the differential brain activation patterns in patients with obsessive compulsive disorder (OCD) and healthy controls during implicit retrieval tasks with emotionally neutral and unpleasant words.
Sixteen patients with OCD (mean age: 31.4±10.1 years) and 16 healthy controls (mean age: 32.6±5.8 years) with no history of neurological or psychiatric illness underwent 3-T fMRI. The stimulation paradigm consisted of the following cycle: rest, encoding of a string of two-syllable words, rest, and retrieval of the previously encoded words with the first consonant omitted.
During the implicit retrieval task with emotionally neutral words, no distinct brain activity was observed in either the patients with OCD or healthy controls. On the other hand, during the retrieval task with unpleasant words, the patients with OCD showed predominant activity in the superior/middle temporal pole, medial superior frontal gyrus, and orbitofrontal cortex (uncorrected p<0.001, extent threshold: 30 voxels), whereas the healthy controls did not show any distinct regions of activation.
This study revealed the differential brain activation patterns between patients with OCD and healthy controls during implicit memory tasks with unpleasant words. Our results suggest that the impact of negative emotion on implicit memory task may be associated with the symptomatology of OCD. This finding may be helpful for understanding the neural mechanisms that underlie implicit memory retrieval, particularly the interaction between emotion and cognition, in patients with OCD.
我们进行功能磁共振成像（fMRI），以辨别强迫症（OCD）患者和健康对照者在使用情感中性和不愉快词汇的内隐记忆任务期间不同的脑激活模式。
16名强迫症患者（平均年龄：31.4±10.1岁）和16名无神经或精神疾病史的健康对照者（平均年龄：32.6±5.8岁）接受了3-T fMRI检查。刺激范式由以下周期组成：休息期、一串双音节词的编码期、休息期，以及对先前编码的词省略首辅音后的检索期。
在使用情感中性词汇的内隐记忆任务期间，强迫症患者和健康对照者均未观察到明显的脑活动。另一方面，在使用不愉快词汇的检索任务期间，强迫症患者在颞上/中极、额上内侧回和眶额皮质表现出优势活动（未校正p<0.001，范围阈值：30体素），而健康对照者未表现出任何明显的激活区域。
本研究揭示了强迫症患者和健康对照者在使用不愉快词汇的内隐记忆任务期间不同的脑激活模式。我们的结果表明，负面情绪对内隐记忆任务的影响可能与强迫症的症状学相关。这一发现可能有助于理解强迫症患者内隐记忆检索的神经机制，尤其是情绪与认知之间的相互作用。
