Wee Jing Zhong, Yang Yun Rui Jasmine, Lee Qian Yi Ruth, Cao Kelly, Chong Chin Ted
Department of Anaesthesiology, Intensive Care and Pain Medicine, Tan Tock Seng Hospital, Singapore.
Singapore Med J. 2016 Sep;57(9):491-6. doi: 10.11622/smedj.2015162. Epub 2015 Nov 13.
Trauma is the fifth principal cause of death in Singapore, with traumatic brain injury (TBI) being the leading specific subordinate cause.
This study was an eight-year retrospective review of the demographic profiles of patients with severe TBI who were admitted to the neurointensive care unit (NICU) of the National Neuroscience Institute at Tan Tock Seng Hospital, Singapore, between 2004 and 2011.
A total of 780 TBI patients were admitted during the study period; 365 (46.8%) patients sustained severe TBI (i.e. Glasgow Coma Scale score ≤ 8), with the majority (75.3%) being male. The ages of patients with severe TBI ranged from 14-93 years, with a bimodal preponderance in young adults (i.e. 21-40 years) and elderly persons (i.e. > 60 years). Motor vehicle accidents (48.8%) and falls (42.5%) were the main mechanisms of injury. Invasive line monitoring was frequently employed; invasive arterial blood pressure monitoring and central venous pressure monitoring were used in 81.6% and 60.0% of the patients, respectively, while intracranial pressure (ICP) measurement was required in 47.4% of the patients. The use of tiered therapy to control ICP (e.g. sedation, osmotherapy, cerebrospinal fluid drainage, moderate hyperventilation and barbiturate-induced coma) converged with international practices.
The high-risk groups for severe TBI were young adults and elderly persons involved in motor vehicle accidents and falls, respectively. In the NICU, the care of patients with severe TBI requires heavy utilisation of resources. The healthcare burden of these patients extends beyond the acute critical care phase.
创伤是新加坡第五大主要死因,其中创伤性脑损伤(TBI)是首要的具体次要死因。
本研究对2004年至2011年间入住新加坡丹戎巴葛医院国家神经科学研究所神经重症监护病房(NICU)的重度TBI患者的人口统计学资料进行了为期八年的回顾性研究。
研究期间共收治780例TBI患者;365例(46.8%)患者为重度TBI(即格拉斯哥昏迷量表评分≤8),其中大多数(75.3%)为男性。重度TBI患者年龄在14 - 93岁之间,在年轻人(即21 - 40岁)和老年人(即>60岁)中呈双峰分布。机动车事故(48.8%)和跌倒(42.5%)是主要的受伤机制。经常采用有创线路监测;分别有81.6%和60.0%的患者使用了有创动脉血压监测和中心静脉压监测,而47.4%的患者需要测量颅内压(ICP)。采用分层治疗来控制ICP(如镇静、渗透性疗法、脑脊液引流、适度过度通气和巴比妥酸盐诱导昏迷)与国际惯例一致。
重度TBI的高危人群分别是涉及机动车事故的年轻人和跌倒的老年人。在NICU,重度TBI患者的护理需要大量资源。这些患者的医疗负担超出急性重症监护阶段。