Zhu Rebecca, Grisotti Gabriella, Salem Ronald R, Khan Sajid A
Yale University School of Medicine, New Haven, CT, USA.
Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.
World J Surg Oncol. 2016 Jan 15;14(1):12. doi: 10.1186/s12957-015-0755-7.
Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, accounts for 3% of newly diagnosed cases of colorectal cancer. While a partial or subtotal colectomy is indicated for early stage disease, there is a paucity of data addressing locally advanced disease involving the foregut.
We report two patients with hereditary nonpolyposis colorectal cancer presenting with locally advanced colon cancer surgically managed by pancreaticoduodenectomy with en bloc partial colectomy and a review of the literature.
Locally advanced colorectal cancer in HNPCC is a rare clinical entity that requires special surgical consideration. Multidisciplinary treatment, including multi-visceral resection, offers the best long-term outcome.
遗传性非息肉病性结直肠癌（HNPCC），即林奇综合征，占新诊断结直肠癌病例的3%。虽然对于早期疾病需行部分或次全结肠切除术，但针对累及前肠的局部晚期疾病的数据却很匮乏。
我们报告了两例遗传性非息肉病性结直肠癌患者，其表现为局部晚期结肠癌，通过胰十二指肠切除术联合整块部分结肠切除术进行手术治疗，并对相关文献进行了综述。
HNPCC中的局部晚期结直肠癌是一种罕见的临床实体，需要特殊的手术考量。多学科治疗，包括多脏器切除，可提供最佳的长期预后。
