类视锥蛋白样蛋白1水平的改变与阿尔茨海默病和额颞叶痴呆的局部神经元丢失相关。
Altered Levels of Visinin-Like Protein 1 Correspond to Regional Neuronal Loss in Alzheimer Disease and Frontotemporal Lobar Degeneration.
作者信息
Kirkwood Caitlin M, MacDonald Matthew L, Schempf Tadhg A, Vatsavayi Anil V, Ikonomovic Milos D, Koppel Jeremy L, Ding Ying, Sun Mai, Kofler Julia K, Lopez Oscar L, Yates Nathan A, Sweet Robert A
出版信息
J Neuropathol Exp Neurol. 2016 Feb;75(2):175-82. doi: 10.1093/jnen/nlv018.
Abstract
Recent studies have implicated the neuronal calcium-sensing protein visinin-like 1 protein (Vilip-1) as a peripheral biomarker in Alzheimer disease (AD), but little is known about expression of Vilip-1 in the brains of patients with AD. We used targeted and quantitative mass spectrometry to measure Vilip-1 peptide levels in the entorhinal cortex (ERC) and the superior frontal gyrus (SF) from cases with early to moderate stage AD, frontotemporal lobar degeneration (FTLD), and cognitively and neuropathologically normal elderly controls. We found that Vilip-1 levels were significantly lower in the ERC, but not in SF, of AD subjects compared to normal controls. In FTLD cases, Vilip-1 levels in the SF were significantly lower than in normal controls. These findings suggest a unique role for cerebrospinal fluid Vilip-1 as a biomarker of ERC neuron loss in AD.
摘要
近期研究表明，神经元钙传感蛋白类视黄醛蛋白样1（Vilip-1）是阿尔茨海默病（AD）的一种外周生物标志物，但对于Vilip-1在AD患者大脑中的表达情况却知之甚少。我们采用靶向定量质谱法，测量了早期至中期AD患者、额颞叶痴呆（FTLD）患者以及认知和神经病理学正常的老年对照者内嗅皮质（ERC）和额上回（SF）中的Vilip-1肽水平。我们发现，与正常对照相比，AD患者ERC中的Vilip-1水平显著降低，但SF中的Vilip-1水平未降低。在FTLD病例中，SF中的Vilip-1水平显著低于正常对照。这些发现表明，脑脊液Vilip-1作为AD中ERC神经元丢失的生物标志物具有独特作用。
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本文引用的文献
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Biol Psychiatry. 2015 Sep 15;78(6):374-85. doi: 10.1016/j.biopsych.2014.12.029. Epub 2015 Jan 30.
2
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Front Psychiatry. 2015 Mar 9;6:30. doi: 10.3389/fpsyt.2015.00030. eCollection 2015.
3
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4
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Sci Transl Med. 2014 Mar 5;6(226):226ra30. doi: 10.1126/scitranslmed.3007901.
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