UK Dementia Research Institute, The University of Edinburgh, Edinburgh, UK.
Center for Discovery Brain Sciences, The University of Edinburgh, Edinburgh, UK.
Eur J Neurosci. 2022 Nov;56(9):5650-5713. doi: 10.1111/ejn.15656. Epub 2022 May 12.
A biomarker associated with cognition in neurodegenerative dementias would aid in the early detection of disease progression, complement clinical staging and act as a surrogate endpoint in clinical trials. The current systematic review evaluates the association between cerebrospinal fluid protein markers of synapse loss and neuronal injury and cognition. We performed a systematic search which revealed 67 studies reporting an association between cerebrospinal fluid markers of interest and neuropsychological performance. Despite the substantial heterogeneity between studies, we found some evidence for an association between neurofilament-light and worse cognition in Alzheimer's diseases, frontotemporal dementia and typical cognitive ageing. Moreover, there was an association between cerebrospinal fluid neurogranin and cognition in those with an Alzheimer's-like cerebrospinal fluid biomarker profile. Some evidence was found for cerebrospinal fluid neuronal pentraxin-2 as a correlate of cognition across dementia syndromes. Due to the substantial heterogeneity of the field, no firm conclusions can be drawn from this review. Future research should focus on improving standardization and reporting as well as establishing the importance of novel markers such as neuronal pentraxin-2 and whether such markers can predict longitudinal cognitive decline.
与神经退行性痴呆认知相关的生物标志物有助于早期发现疾病进展，补充临床分期，并在临床试验中作为替代终点。本系统评价评估了与突触丧失和神经元损伤相关的脑脊液蛋白标志物与认知之间的关联。我们进行了系统搜索，结果显示有 67 项研究报告了脑脊液中感兴趣的标志物与神经心理学表现之间的关联。尽管研究之间存在很大的异质性，但我们发现神经丝轻链与阿尔茨海默病、额颞叶痴呆和典型认知老化患者认知能力下降之间存在一定的关联。此外，在具有阿尔茨海默病样脑脊液生物标志物特征的患者中，脑脊液神经颗粒蛋白与认知之间存在关联。有证据表明脑脊液神经元五聚素-2与痴呆综合征患者的认知能力相关。由于该领域的异质性很大，因此无法从本次综述中得出明确的结论。未来的研究应侧重于改善标准化和报告，并确定新标志物（如神经元五聚素-2）的重要性，以及这些标志物是否可以预测纵向认知能力下降。
