微卫星不稳定性在MRI阴性的癫痫性局灶性皮质发育不良患者中的应用。
Application of MSI in MRI-negative focal cortical dysplasia patients with epilepsy.
作者信息
Sun Jilin, Jia Xiuchuan, Liu Xi, Wu Jie, Li Sumin
机构信息
Department of Radiology, Hebei General Hospital Shijiazhuang, China.
出版信息
Int J Clin Exp Med. 2015 Oct 15;8(10):18427-33. eCollection 2015.
BACKGROUND
Focal cortical dysplasia (FCD) is the most common cause of intractable epilepsy in children and adolescent.
PURPOSE
To evaluate the application value of magnetic source imaging (MSI) in treatment of magnetic resonance imaging (MRI)-negative FCD patients with epilepsy.
METHODS
MSI characteristics of 17 cases of MRI-negative focal cortical dysplasia patients with epilepsy were retrospectively analyzed. All patients were treated by surgery.
RESULTS
In 17 patients, there were 3 cases of FCD Ia, 7 cases of FCDIb, 3 cases of FCDIIa and 4 cases of FCDIIb. FCD was located at temporal lobe in 8 cases, occipital lobe in 3 cases, frontal lobe in 2 cases and two lobes in 4 cases. In follow-up, 14 patients obtained satisfied curative effect. 1 patient was improved significantly and 2 patients were fine. The concordance between MSI and electrocorticogram in localizing epileptogenic foci was 65%.
CONCLUSION
MSI is a new prospective noninvasive functional neuroimaging technique for identifying and delineating epileptogenic foci in MRI-negative FCD patients.
背景
局灶性皮质发育不良（FCD）是儿童和青少年难治性癫痫最常见的病因。
目的
评估磁源成像（MSI）在治疗磁共振成像（MRI）阴性的癫痫FCD患者中的应用价值。
方法
回顾性分析17例MRI阴性的局灶性皮质发育不良癫痫患者的MSI特征。所有患者均接受手术治疗。
结果
17例患者中，FCD Ia型3例，FCD Ib型7例，FCD IIa型3例，FCD IIb型4例。FCD位于颞叶8例，枕叶3例，额叶2例，两叶4例。随访中，14例患者疗效满意。1例患者明显改善，2例患者情况良好。MSI与皮质脑电图在癫痫灶定位上的一致性为65%。
结论
MSI是一种新的前瞻性无创功能神经成像技术，用于识别和描绘MRI阴性FCD患者的癫痫灶。
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