Hassali Mohamed Azmi, Wong Zhi Yen, Alrasheedy Alian A, Saleem Fahad, Mohamad Yahaya Abdul Haniff, Aljadhey Hisham
Discipline of Social & Administrative Pharmacy, School of Pharmaceutical Sciences, UniversitiSains Malaysia, Penang, Malaysia.
Pharmacy Department, Hospital TelukIntan, Perak, Malaysia.
SAGE Open Med. 2014 Nov 5;2:2050312114555722. doi: 10.1177/2050312114555722. eCollection 2014.
To investigate the impact of an educational intervention on doctors' knowledge and perceptions towards generic medicines and their generic (international non-proprietary name) prescribing practice.
This is a single-cohort pre-/post-intervention pilot study. The study was conducted in a tertiary care hospital in Perak, Malaysia. All doctors from the internal medicine department were invited to participate in the educational intervention. The intervention consisted of an interactive lecture, an educational booklet and a drug list. Doctors' knowledge and perceptions were assessed by using a validated questionnaire, while the international non-proprietary name prescribing practice was assessed by screening the prescription before and after the intervention.
The intervention was effective in improving doctors' knowledge towards bioequivalence, similarity of generic medicines and safety standards required for generic medicine registration (p = 0.034, p = 0.034 and p = 0.022, respectively). In terms of perceptions towards generic medicines, no significant changes were noted (p > 0.05). Similarly, no impact on international non-proprietary name prescribing practice was observed after the intervention (p > 0.05).
Doctors had inadequate knowledge and misconceptions about generic medicines before the intervention. Moreover, international non-proprietary name prescribing was not a common practice. However, the educational intervention was only effective in improving doctors' knowledge of generic medicines.
探讨一项教育干预措施对医生关于仿制药及其通用名(国际非专利名)处方实践的知识和认知的影响。
这是一项单队列干预前/后试点研究。该研究在马来西亚霹雳州的一家三级护理医院进行。内科的所有医生均受邀参与此次教育干预。干预措施包括一场互动讲座、一本教育手册和一份药品清单。通过使用一份经过验证的问卷来评估医生的知识和认知,同时通过筛查干预前后的处方来评估国际非专利名的处方实践。
该干预措施在提高医生对生物等效性、仿制药相似性以及仿制药注册所需安全标准的知识方面有效(分别为p = 0.034、p = 0.034和p = 0.022)。在对仿制药的认知方面,未观察到显著变化(p > 0.05)。同样,干预后未观察到对国际非专利名处方实践有影响(p > 0.05)。
干预前医生对仿制药的知识不足且存在误解。此外,使用国际非专利名进行处方并非常见做法。然而,此次教育干预仅在提高医生对仿制药的知识方面有效。