Kahwash Basil M, Nowacki Nicholas B, Kahwash Samir B
Department of Medicine, University of Indiana, Indianapolis, IN 46202, USA.
Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Case Rep Hematol. 2015;2015:163857. doi: 10.1155/2015/163857. Epub 2015 Dec 8.
We discuss the significance of neutrophils with increased, aberrant nuclear projections mimicking "barbed-wire" in a newborn child with trisomy 18 (T18). Increased, aberrant nuclear projections have been previously reported in trisomy of the D group of chromosomes (chromosomes 13, 14, and 15), and we report similar findings in a patient with T18. The peripheral blood smear showed relative neutrophilia with the majority (37%) of neutrophils showing two or more thin, rod-shaped or spike-shaped, and often pedunculated aberrant nuclear projections. The number of projections ranged from 2 to 6 per cell, averaged 2 per affected neutrophil, and ranged in length from 0.22 μm to 0.83 μm. This case confirms that the morphologic finding described is not restricted to trisomy of one of the chromosomes in group D, as implied in the literature.
我们讨论了在一名18三体综合征（T18）新生儿中，具有模仿“铁丝网”的增多、异常核突起的中性粒细胞的意义。此前曾报道过D组染色体（13号、14号和15号染色体）三体中出现增多、异常的核突起，我们在一名T18患者中报告了类似的发现。外周血涂片显示相对中性粒细胞增多，大多数（37%）中性粒细胞有两个或更多细的、杆状或尖状且通常有蒂的异常核突起。每个细胞的突起数量为2至6个，每个受影响的中性粒细胞平均为2个，长度范围为0.22μm至0.83μm。该病例证实，文献中所暗示的，上述形态学发现并不局限于D组中的某一条染色体三体。
