肝脏纤维化中的一氧化氮：诱导型一氧化氮合酶的作用
Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase.
作者信息
Iwakiri Yasuko
机构信息
Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.
出版信息
Clin Mol Hepatol. 2015 Dec;21(4):319-25. doi: 10.3350/cmh.2015.21.4.319. Epub 2015 Dec 24.
Abstract
The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.
摘要
一氧化氮合酶的诱导型（iNOS）在病理状态下的肝细胞中表达。其诱导作用参与肝纤维化的发展，因此iNOS可能成为肝纤维化的治疗靶点。本综述总结了iNOS在肝纤维化中的作用，重点关注：1）iNOS生物学；2）表达iNOS的肝细胞；3）与iNOS相关的治疗策略；4）未来方向。
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