Meyer-Schwesinger Catherine
Internal Medicine, Nephrology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nephron. 2016;132(2):101-9. doi: 10.1159/000442180. Epub 2016 Jan 16.
The adult kidney has a remarkable ability to survive injury and restore function despite a limited turnover of cells under physiologic conditions. This accounts both for the tubular and to a lesser extent for the glomerular compartment. It is an ongoing debate whether renal repair is carried out by self-duplication/de-differentiation of mature resident renal cells, or by specialized renal progenitors residing in specific niches or by circulating bone marrow-derived stem cells. In this review, the existence of renal progenitor cells and their contribution for regeneration of the tubular and the glomerular compartment are discussed, highlighting landmark publications of recent years.
尽管在生理条件下细胞更新有限，但成年肾脏具有显著的能力来承受损伤并恢复功能。这在肾小管方面表现明显，在肾小球部分程度稍轻。关于肾脏修复是通过成熟的常驻肾细胞自我复制/去分化，还是通过存在于特定微环境中的特殊肾祖细胞，抑或是通过循环的骨髓来源干细胞来进行，目前仍在争论中。在这篇综述中，我们讨论了肾祖细胞的存在及其对肾小管和肾小球部分再生的贡献，并重点介绍了近年来具有里程碑意义的出版物。
