营养生物标志物临界值综述
A Review of Cutoffs for Nutritional Biomarkers.
作者信息
Raghavan Ramkripa, Ashour Fayrouz Sakr, Bailey Regan
机构信息
Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD;
Department of Nutrition and Food Science, University of Maryland, College Park, MD; and.
出版信息
Adv Nutr. 2016 Jan 15;7(1):112-20. doi: 10.3945/an.115.009951. Print 2016 Jan.
The nutritional status of an individual or population needs to be assessed through valid and reliable biomarkers. Cutoffs generally have an underlying relation to health status and are one of the important quantitative criteria against which biomarker outputs are compared. For this reason, cutoffs are integral for surveys, surveillance, screening, interventions, monitoring, and evaluation. Despite their importance, nutritional biomarker cutoffs have not been adequately addressed in the literature. Furthermore, the field has not reached a consensus on which cutoff to use for each biomarker, and different cutoffs are often used for the same biomarkers in published studies. This review provides a comprehensive overview of cutoffs related to nutritional biomarkers and highlights some of the high-priority research gaps and challenges of using micronutrient case studies.
个体或人群的营养状况需要通过有效且可靠的生物标志物来评估。临界值通常与健康状况存在内在联系，是用于比较生物标志物输出结果的重要定量标准之一。因此，临界值对于调查、监测、筛查、干预、监测和评估而言不可或缺。尽管其很重要，但营养生物标志物的临界值在文献中尚未得到充分探讨。此外，对于每种生物标志物应使用何种临界值，该领域尚未达成共识，并且在已发表的研究中，相同的生物标志物常常使用不同的临界值。本综述全面概述了与营养生物标志物相关的临界值，并着重介绍了一些高优先级的研究空白以及使用微量营养素案例研究时面临的挑战。
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